Document Detail


Down-regulated expression of Notch signaling molecules in human endometrial cancer.
MedLine Citation:
PMID:  23315219     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Notch signaling pathway is a highly conserved developmental pathway, which plays an important role in the regulation of cellular proliferation, differentiation and apoptosis. Deregulation of Notch pathway has been connected with the carcinogenesis in a variety of cancers. In this study, we investigated the expression of Notch receptors (NOTCH1, NOTCH2, NOTCH3 and NOTCH4), ligands (JAG1, JAG2 and DLL1) and target gene HES1. Fifty paired samples of endometrial cancer and adjacent nontumor endometrial tissue from endometrial cancer patients were analyzed by quantitative PCR. The mRNA levels of all investigated molecules were lower in endometrial cancer compared to adjacent nontumor tissue. The expression of NOTCH1, NOTCH4 and DLL1 in IB stage adenocarcinoma was significantly lower (P < 0.05) than the expression in IA stage adenocarcinoma. Significant correlations were found between mRNA expression levels of Notch target gene HES1 and several Notch signaling molecules: NOTCH1, NOTCH3, DLL1 (P < 0.001) and NOTCH2, JAG2 (P < 0.05). This supports the notion that Notch pathway can function as tumor suppressor in human endometrial cancer.
Authors:
Violeta Jonusiene; Ausra Sasnauskiene; Nadezda Lachej; Daiva Kanopiene; Daiva Dabkeviciene; Sofija Sasnauskiene; Birute Kazbariene; Janina Didziapetriene
Related Documents :
8586519 - Multicystic recurrence of hydrocele testis after sclerosing with polidocanol followed b...
16389149 - Preoperative evaluation of colorectal cancer.
24769729 - Arhi (diras3) induces autophagy in ovarian cancer cells by downregulating the epidermal...
22424079 - E-counseling in psychosocial cancer care: a survey of practice, attitudes, and training...
23814519 - Acute kidney injury and bisphosphonate use in cancer: a report from the research on adv...
24863259 - Targeting pi3k/akt/mtor pathway in non small cell lung cancer.
12802129 - Meditation as a complementary therapy in cancer.
17034519 - Specialist dermatology clinics for organ transplant recipients significantly improve co...
16823169 - Fertility sparing options for breast cancer patients.
Publication Detail:
Type:  Journal Article     Date:  2013-01-13
Journal Detail:
Title:  Medical oncology (Northwood, London, England)     Volume:  30     ISSN:  1559-131X     ISO Abbreviation:  Med. Oncol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-01-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9435512     Medline TA:  Med Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  438     Citation Subset:  IM    
Affiliation:
Department of Biochemistry and Biophysics, Faculty of Natural Sciences, Vilnius University, Vilnius, Lithuania, violeta.jonusiene@gf.vu.lt.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Frequent CpG methylation of ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) in sporadic and heredita...
Next Document:  Clinical outcomes in elderly patients administered gefitinib as first-line treatment in epidermal gr...