Document Detail

Doublet translocation at GGA is mediated directly by mutant tRNA(2Gly).
MedLine Citation:
PMID:  1597432     Owner:  NLM     Status:  MEDLINE    
Members of the sufS class of -1 frameshift suppressors have alterations of the GGA/G-decoding tRNA(2Gly). Suppressor-promoted frameshifting at GGA was shown in this study to be directly mediated by the mutant tRNA(2Gly). We disproved the possibility that, in the presence of the compromised mutant tRNA(2Gly), either wild-type tRNA(1Gly), wild-type tRNA(3Gly), a GGA-reading mutant form of tRNA(3Gly), or any other agent suppresses the frameshift mutation trpE91.
F T Pagel; T M Tuohy; J F Atkins; E J Murgola
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of bacteriology     Volume:  174     ISSN:  0021-9193     ISO Abbreviation:  J. Bacteriol.     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-07-07     Completed Date:  1992-07-07     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985120R     Medline TA:  J Bacteriol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  4179-82     Citation Subset:  IM    
Department of Molecular Genetics, University of Texas M. D. Anderson Cancer Center, Houston 77030.
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MeSH Terms
Escherichia coli / genetics*
Frameshift Mutation / genetics*
Genes, Suppressor / genetics*
Mutation / genetics
Polymerase Chain Reaction
RNA, Transfer, Gly / genetics*
Translocation, Genetic
Grant Support
Reg. No./Substance:
0/RNA, Transfer, Gly

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