| Doublet translocation at GGA is mediated directly by mutant tRNA(2Gly). | |
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MedLine Citation:
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PMID: 1597432 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Members of the sufS class of -1 frameshift suppressors have alterations of the GGA/G-decoding tRNA(2Gly). Suppressor-promoted frameshifting at GGA was shown in this study to be directly mediated by the mutant tRNA(2Gly). We disproved the possibility that, in the presence of the compromised mutant tRNA(2Gly), either wild-type tRNA(1Gly), wild-type tRNA(3Gly), a GGA-reading mutant form of tRNA(3Gly), or any other agent suppresses the frameshift mutation trpE91. |
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Authors:
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F T Pagel; T M Tuohy; J F Atkins; E J Murgola |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of bacteriology Volume: 174 ISSN: 0021-9193 ISO Abbreviation: J. Bacteriol. Publication Date: 1992 Jun |
Date Detail:
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Created Date: 1992-07-07 Completed Date: 1992-07-07 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2985120R Medline TA: J Bacteriol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 4179-82 Citation Subset: IM |
Affiliation:
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Department of Molecular Genetics, University of Texas M. D. Anderson Cancer Center, Houston 77030. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Escherichia coli
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genetics* Frameshift Mutation / genetics* Genes, Suppressor / genetics* Mutation / genetics Polymerase Chain Reaction RNA, Transfer, Gly / genetics* Translocation, Genetic |
| Grant Support | |
ID/Acronym/Agency:
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GM21499/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/RNA, Transfer, Gly |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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