| Double versus single intrauterine insemination for unexplained infertility: a meta-analysis of randomized trials. | |
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MedLine Citation:
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PMID: 19665705 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the effect of double versus single intrauterine insemination (IUI) per treatment cycle in women with unexplained infertility. DESIGN: Meta-analysis of randomized controlled trials. MAIN OUTCOME MEASURE(S): Clinical pregnancy rates per couple. INTERVENTION(S): Electronic searches of the Cochrane Central Trials Registry and Medline without year and language restriction through March 2009; hand searching of the abstract books of the European Society of Human Reproduction and Embryology and American Society for Reproductive Medicine annual meetings (2001-2008). RESULT(S): Six randomized trials, involving 829 women, were included in the analysis. Fifty-four (13.6%) clinical pregnancies were recorded for treatment with double IUI and 62 (14.4%) for treatment with single IUI. There was no significant difference between the single and double IUI groups in the probability for clinical pregnancy (odds ratio, 0.92; 95% confidence interval, 0.58-1.45; P=0.715). CONCLUSION(S): Double IUI offers no clear benefit in the overall clinical pregnancy rate in couples with unexplained infertility. |
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Authors:
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Nikolaos P Polyzos; Spyridon Tzioras; Davide Mauri; Athina Tatsioni |
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Publication Detail:
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Type: Journal Article; Meta-Analysis Date: 2009-08-08 |
Journal Detail:
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Title: Fertility and sterility Volume: 94 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-27 Completed Date: 2010-09-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 1261-6 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Section of Obstetrics and Gynaecology and Public Health, Panhellenic Association for Continual Medical Research, Athens, Greece. n.polyzos@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Algorithms Family Characteristics Female Geography Humans Infertility / etiology, therapy* Insemination, Artificial / methods* Male Pregnancy Pregnancy Rate Quality Control Randomized Controlled Trials as Topic / statistics & numerical data* Uterus |
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