Document Detail

Double 9;22 translocation with hyperdiploidy appearing in blastic transformation of chronic granulocytic leukemia.
MedLine Citation:
PMID:  6958359     Owner:  NLM     Status:  MEDLINE    
Chromosome studies in a 26-year-old female with Ph1-positive chronic granulocytic leukemia showed the development of both hyperdiploid and tetraploid cell lines in the blastic transformation phase. An additional 9;22 translocation and additional chromosomes No. 8, 11, 13 and 22 were found in the hyperdiploid cell line. This unusual finding suggests that the hyperdiploidy may have developed from misdivisions in the tetraploid cell line rather than by the more accepted mechanism of nondisjunction or selective endoreduplication from a diploid cell.
P Rajasekariah; I Illes; O M Garson
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  7     ISSN:  0165-4608     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  1982 Sep 
Date Detail:
Created Date:  1983-01-19     Completed Date:  1983-01-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  85-8     Citation Subset:  IM    
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MeSH Terms
Bone Marrow / ultrastructure
Chromosome Banding
Chromosomes, Human, 21-22 and Y / ultrastructure*
Chromosomes, Human, 6-12 and X / ultrastructure*
Leukemia, Myeloid / genetics*
Translocation, Genetic*

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