| Double red cell concentrates -in vitro quality after delayed refrigeration. | |
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MedLine Citation:
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PMID: 20456686 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Automated collection of red cell concentrates (RCC) presents a number of potential advantages to donors, blood services and recipients, and allows the collection of finished components from sites that are remote from a blood centre. However, data are lacking on how long the collected RCC may be stored at ambient temperature prior to their final storage at 4 °C. In this study, the Haemonetics Cymbal device was used to collect RCC using citrate, phosphate and dextrose (CPD-50) anticoagulant. A total of 10 procedures each yielded two leucodepleted RCC in saline, adenine, glucose and mannitol (SAGM) additive solution. One of each pair of RCC was kept warm in an insulated transport bag for 8 h and the other for 6 h. In vitro assessments of the quality of the RCC were made during subsequent 42-day storage of the RCC at 2-6 °C, and compared with reference data. All collected RCC were within UK and European limits for volume, haematocrit and haemoglobin content. Haemolysis was within specification at Day 42 and was no different in RCC held warm for 6 or 8 hours, but tended to be higher than reference data from whole blood derived RCC. ATP, 2,3 DPG and supernatant potassium levels were all similar in RCC held warm for 6 or 8 hours and reference data. We conclude that the Cymbal device may be used to collect two RCC in SAGM, and the in vitro assessment indicates that RCC may be stored without refrigeration for up to 8 h following collection, prior to final storage at 4 °C. |
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Authors:
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S Thomas; Y Bekoe; S Uddin; M Beard; R Cardigan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Transfusion medicine (Oxford, England) Volume: 20 ISSN: 1365-3148 ISO Abbreviation: Transfus Med Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-11-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9301182 Medline TA: Transfus Med Country: England |
Other Details:
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Languages: eng Pagination: 315-21 Citation Subset: IM |
Copyright Information:
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© 2010 The Authors. Transfusion Medicine © 2010 British Blood Transfusion Society. |
Affiliation:
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Component Development Laboratory, NHS Blood and Transplant, Brentwood, UK. stephen.thomas@nhsbt.nhs.uk |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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