Document Detail

Double-blind; placebo-controlled trial of piperacillin prophylaxis in preterm membrane rupture.
MedLine Citation:
PMID:  8238159     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We attempted to test whether antibiotic therapy prolongs pregnancy in preterm premature rupture of membranes, because preterm premature rupture of membranes is frequently associated with chorionic-decidual infection. STUDY DESIGN: Women with preterm premature rupture of membranes and a singleton gestation at 24 to 34 completed weeks were randomized to receive either piperacillin 3 gm or placebo intravenously every 6 hours for 72 hours and were managed conservatively until spontaneous delivery, chorioamnionitis, or fetal distress. RESULTS: Between January 1987 and January 1992, a total of 75 patients were randomized to receive piperacillin (n = 38) or placebo (n = 37). There were no differences between the piperacillin group and the placebo group in mean gestational age at randomization (30.2 +/- 3 vs 30.3 +/- 2.9 weeks). However, a greater number of patients had pregnancy prolonged beyond 7 days (42.1% vs 10.8% p = 0.005) and the mean latency period was significantly prolonged (11.4 +/- 18.8 vs 6.1 +/- 13.6 days, p = 0.001) in the piperacillin group compared with the control groups. CONCLUSIONS: Use of intravenous piperacillin for 72 hours in preterm premature rupture of membranes significantly prolongs the latency period between membrane rupture and delivery.
C J Lockwood; K Costigan; A Ghidini; R Wein; D Chien; B L Brown; M Alvarez; C L Cetrulo
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  169     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1993-11-26     Completed Date:  1993-11-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  970-6     Citation Subset:  AIM; IM    
Department of Obstetrics, Gynecology and Reproductive Medicine, Mount Sinai School of Medicine, New York, New York.
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MeSH Terms
Birth Weight / drug effects
Chorioamnionitis / complications,  prevention & control*
Double-Blind Method
Fetal Membranes, Premature Rupture / complications,  drug therapy*
Injections, Intravenous
Length of Stay
Life Tables
Obstetric Labor, Premature / etiology,  prevention & control*
Piperacillin / administration & dosage,  therapeutic use*
Pregnancy Outcome
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Treatment Outcome
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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