| Double-peaked positive chronotropic responses of isolated and cross-perfused dog atria to ATP. | |
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MedLine Citation:
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PMID: 6668765 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of a large amount of adenosine and ATP (100 to 3000 micrograms) were investigated on sinus rate and developed tension, using the isolated dog atrium which was perfused with arterial blood from a heparinized donor dog. Each of the substances used for study was administered into the cannulated sinus node artery of the isolated atrium. Adenosine caused monophasic negative chronotropic and inotropic effects in a dose-related manner. However, ATP induced two-peaked positive chronotropic phases during a long-lasting negative chronotropic phase, i.e., initially, brief positive (t-1) effects and secondarily, relatively longer positive chronotropic (t-2) effects. These responses were repetitively induced during the experiment. The t-1 and t-2 were not influenced by treatment with propranolol which significantly blocked the positive chronotropic effect of norepinephrine. Aminophylline treatment significantly suppressed t-2 but not t-1. Quinidine (100-1000 micrograms) did not affect either the t-1 or t-2. It is suggested that ATP-induced tachycardia in the dog is partially due to activation of the P1-purinoceptors named by Burnstock. |
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Authors:
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S Chiba; M Kobayashi; M Shimotori |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Japanese journal of pharmacology Volume: 33 ISSN: 0021-5198 ISO Abbreviation: Jpn. J. Pharmacol. Publication Date: 1983 Dec |
Date Detail:
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Created Date: 1984-04-02 Completed Date: 1984-04-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2983305R Medline TA: Jpn J Pharmacol Country: JAPAN |
Other Details:
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Languages: eng Pagination: 1191-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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pharmacology Adenosine Triphosphate / pharmacology* Aminophylline / pharmacology Animals Dogs Female Heart Rate / drug effects* Male Myocardial Contraction / drug effects Perfusion Propranolol / pharmacology Quinidine / pharmacology Stimulation, Chemical |
| Chemical | |
Reg. No./Substance:
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317-34-0/Aminophylline; 525-66-6/Propranolol; 56-54-2/Quinidine; 56-65-5/Adenosine Triphosphate; 58-61-7/Adenosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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