Document Detail

Double-peaked high-pressure zone at the esophagogastric junction in controls and in patients with a hiatal hernia: a study using high-resolution manometry.
MedLine Citation:
PMID:  15387333     Owner:  NLM     Status:  MEDLINE    
The lower esophageal high-pressure zone (HPZ) consists of the intrinsic lower esophageal sphincter (LES) and the diaphragmatic sphincter. In patients with a hiatal hernia these constituents are separated. We performed high-resolution manometry of the esophagogastric HPZ in six controls, six patients with a small hernia, and six patients with a large hernia. Prevalence of a double-peak pressure profile of the HPZ was noted. Pressures and distances between the peaks were assessed. Prevalence of the double-peak profile was similar between patients with a small hernia and controls, but patients with a large hernia showed a higher prevalence with inspiration (P < 0.05) than the others. The distance between the two peaks was larger in patients with a large hernia (P < 0.05). In conclusion, high-resolution manometry makes it possible to distinguish the diaphragmatic pressure component from the LES. Two pressure peaks can be found both in hernia patients and in healthy volunteers.
A J Bredenoord; B L A M Weusten; S Carmagnola; A J P M Smout
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  49     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-09-24     Completed Date:  2004-11-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1128-35     Citation Subset:  AIM; IM    
Department of Gastroenterology, Sint Antonius Hospital, Nieuwegein, The Netherlands.
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MeSH Terms
Esophagogastric Junction / physiology*,  physiopathology*
Hernia, Hiatal / physiopathology*
Manometry / methods*
Middle Aged

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