| Double nucleophilic attack on isocyanide carbon: a synthetic strategy for 7-aza-tetrahydroindoles. | |
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MedLine Citation:
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PMID: 23145430 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A novel and efficient route for the synthesis of 7-aza-tetrahydroindoles from N-aryl/alkyl-alkenoylacetamides and ethyl isocyanoacetate is described. A mechanism, involving a stepwise [3+2] cycloaddition-intramolecular aza-Michael addition cascade, is proposed that explains the origin of the double nucleophilic attack on the isocyanide carbon atom. |
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Authors:
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Yifei Li; Xianxiu Xu; Chunyu Xia; Lingjuan Zhang; Ling Pan; Qun Liu |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-12 |
Journal Detail:
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Title: Chemical communications (Cambridge, England) Volume: - ISSN: 1364-548X ISO Abbreviation: Chem. Commun. (Camb.) Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9610838 Medline TA: Chem Commun (Camb) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Chemistry, Northeast Normal University, Changchun 130024, China. xuxx677@nenu.edu.cn liuqun@nenu.edu.cn. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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