| Double-masked cross-over comparison of Ganda 1.02 (guanethidine 1% and adrenaline 0.2% mixture) with gutt. adrenaline 1% (Simplene 1%) and with pilocarpine 1% (Sno-Pilo 1%). | |
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MedLine Citation:
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PMID: 7004478 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A trial of the efficacy of low-concentration nonmiotic therapy was carried out, the aim being to minimise the side effects produced by 1% adrenaline or pilocarpine. A total of 77 eyes with open-angle glaucoma were studied in both parts of the trial. Thirty-nine eyes had a base-line pressure of over 28 mmHg and 28 eyes a pressure of 30 mmHg or over. In the comparison between Ganda 1.02 and adrenaline 1% (Simplene) the mean lowering of intraocular pressure was 8.6 mmHg with Ganda and 7.69 mmHg with Simplene. In the comparison between Ganda 1.02 and pilocarpine 1% (Sno-Pilo) the mean decrease was 6.34 mmHg with Ganda and 6.13 mmHg with Sno-Pilo. The resulting falls in intraocular pressure were highly significant statistically, but the differences between the effects of the 3 drugs were not significant. No significant side effects were reported with Ganda 1.02, and in particular no ptosis or superficial punctate staining of the cornea was noted. |
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Authors:
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J H Romano; S Nagasubramanian; D Poinoosawmy |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: The British journal of ophthalmology Volume: 65 ISSN: 0007-1161 ISO Abbreviation: Br J Ophthalmol Publication Date: 1981 Jan |
Date Detail:
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Created Date: 1981-03-17 Completed Date: 1981-03-17 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0421041 Medline TA: Br J Ophthalmol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 50-2 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Clinical Trials as Topic Double-Blind Method Drug Combinations Epinephrine / adverse effects, therapeutic use* Glaucoma / drug therapy* Guanethidine / adverse effects, therapeutic use* Humans Pilocarpine / adverse effects, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Drug Combinations; 51-43-4/Epinephrine; 55-65-2/Guanethidine; 92-13-7/Pilocarpine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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