Document Detail

Double-masked cross-over comparison of Ganda 1.02 (guanethidine 1% and adrenaline 0.2% mixture) with gutt. adrenaline 1% (Simplene 1%) and with pilocarpine 1% (Sno-Pilo 1%).
MedLine Citation:
PMID:  7004478     Owner:  NLM     Status:  MEDLINE    
A trial of the efficacy of low-concentration nonmiotic therapy was carried out, the aim being to minimise the side effects produced by 1% adrenaline or pilocarpine. A total of 77 eyes with open-angle glaucoma were studied in both parts of the trial. Thirty-nine eyes had a base-line pressure of over 28 mmHg and 28 eyes a pressure of 30 mmHg or over. In the comparison between Ganda 1.02 and adrenaline 1% (Simplene) the mean lowering of intraocular pressure was 8.6 mmHg with Ganda and 7.69 mmHg with Simplene. In the comparison between Ganda 1.02 and pilocarpine 1% (Sno-Pilo) the mean decrease was 6.34 mmHg with Ganda and 6.13 mmHg with Sno-Pilo. The resulting falls in intraocular pressure were highly significant statistically, but the differences between the effects of the 3 drugs were not significant. No significant side effects were reported with Ganda 1.02, and in particular no ptosis or superficial punctate staining of the cornea was noted.
J H Romano; S Nagasubramanian; D Poinoosawmy
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  65     ISSN:  0007-1161     ISO Abbreviation:  Br J Ophthalmol     Publication Date:  1981 Jan 
Date Detail:
Created Date:  1981-03-17     Completed Date:  1981-03-17     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  50-2     Citation Subset:  IM    
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MeSH Terms
Clinical Trials as Topic
Double-Blind Method
Drug Combinations
Epinephrine / adverse effects,  therapeutic use*
Glaucoma / drug therapy*
Guanethidine / adverse effects,  therapeutic use*
Pilocarpine / adverse effects,  therapeutic use*
Reg. No./Substance:
0/Drug Combinations; 51-43-4/Epinephrine; 55-65-2/Guanethidine; 92-13-7/Pilocarpine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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