Document Detail

Double-masked comparative study of UF-021 and timolol ophthalmic solutions in patients with primary open-angle glaucoma or ocular hypertension.
MedLine Citation:
PMID:  8145398     Owner:  NLM     Status:  MEDLINE    
A double-masked comparative clinical study of UF-021 (Rescula), a unique prostaglandin-related compound, was carried out at 18 centers with timolol maleate 0.5% ophthalmic solution as an active reference drug. After a wash-out period, UF-021 (0.12%) or timolol (0.5%) was given topically twice a day for 12 weeks to 158 patients with primary open-angle glaucoma or ocular hypertension, in a randomized double-masked manner. Both groups showed a significant reduction in intraocular pressure from the second week to the end of the study. In overall improvement rating, 91.4% of the cases (64/70) in the UF-021 group and 88.3% (68/77) in the timolol group were judged to be "Extremely improved" or "Improved". Five and 4 cases reported having side effects in the UF-021 and timolol groups, respectively, but none of the cases required any change or discontinuation of treatment. While UF-021 did not affect blood pressure, both systolic and diastolic blood pressures in the timolol group were significantly decreased. These results suggest that UF-021 (0.12%) has the potential to lower intraocular pressure equivalent to timolol (0.5%), while having no effect on cardiovascular functions.
I Azuma; K Masuda; Y Kitazawa; M Takase; H Yamamura
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Japanese journal of ophthalmology     Volume:  37     ISSN:  0021-5155     ISO Abbreviation:  Jpn. J. Ophthalmol.     Publication Date:  1993  
Date Detail:
Created Date:  1994-05-02     Completed Date:  1994-05-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0044652     Medline TA:  Jpn J Ophthalmol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  514-25     Citation Subset:  IM    
Department of Ophthalmology, Osaka Medical College, Japan.
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MeSH Terms
Administration, Topical
Blood Pressure / drug effects
Dinoprost / administration & dosage,  adverse effects,  analogs & derivatives*,  therapeutic use
Double-Blind Method
Glaucoma, Open-Angle / drug therapy*
Intraocular Pressure
Ocular Hypertension / drug therapy*
Ophthalmic Solutions
Timolol / administration & dosage,  adverse effects,  therapeutic use*
Reg. No./Substance:
0/Ophthalmic Solutions; 26839-75-8/Timolol; 551-11-1/Dinoprost; 69553-75-9/isopropyl unoprostone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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