| Double-masked comparative study of UF-021 and timolol ophthalmic solutions in patients with primary open-angle glaucoma or ocular hypertension. | |
MedLine Citation:
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PMID: 8145398 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A double-masked comparative clinical study of UF-021 (Rescula), a unique prostaglandin-related compound, was carried out at 18 centers with timolol maleate 0.5% ophthalmic solution as an active reference drug. After a wash-out period, UF-021 (0.12%) or timolol (0.5%) was given topically twice a day for 12 weeks to 158 patients with primary open-angle glaucoma or ocular hypertension, in a randomized double-masked manner. Both groups showed a significant reduction in intraocular pressure from the second week to the end of the study. In overall improvement rating, 91.4% of the cases (64/70) in the UF-021 group and 88.3% (68/77) in the timolol group were judged to be "Extremely improved" or "Improved". Five and 4 cases reported having side effects in the UF-021 and timolol groups, respectively, but none of the cases required any change or discontinuation of treatment. While UF-021 did not affect blood pressure, both systolic and diastolic blood pressures in the timolol group were significantly decreased. These results suggest that UF-021 (0.12%) has the potential to lower intraocular pressure equivalent to timolol (0.5%), while having no effect on cardiovascular functions. |
Authors:
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I Azuma; K Masuda; Y Kitazawa; M Takase; H Yamamura |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
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Title: Japanese journal of ophthalmology Volume: 37 ISSN: 0021-5155 ISO Abbreviation: Jpn. J. Ophthalmol. Publication Date: 1993 |
Date Detail:
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Created Date: 1994-05-02 Completed Date: 1994-05-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0044652 Medline TA: Jpn J Ophthalmol Country: JAPAN |
Other Details:
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Languages: eng Pagination: 514-25 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Osaka Medical College, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Blood Pressure / drug effects Dinoprost / administration & dosage, adverse effects, analogs & derivatives*, therapeutic use Double-Blind Method Glaucoma, Open-Angle / drug therapy* Humans Intraocular Pressure Ocular Hypertension / drug therapy* Ophthalmic Solutions Timolol / administration & dosage, adverse effects, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Ophthalmic Solutions; 26839-75-8/Timolol; 551-11-1/Dinoprost; 69553-75-9/isopropyl unoprostone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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