Document Detail


Double isotope derivative dilution method for the determination of prostaglandin F and E type metabolites in urine.
MedLine Citation:
PMID:  341230     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This method was developed for the quantitative determination of the main ureinary metabolite (MUM) of prostaglandin (PG) F and E type in man or experimental animal. This method was based on the extraction of PG-MUM after addition of 3H-PG-MUM, the esterification with 14C-acetic anhydride and the separation and purification by column chromatography. Excretion values of adult men were PGF-MUM 1.46--15.01 microgram/8 hr (n=11), PGE-MUM 0.8*--15.42 microgram/8 hr; and with women, PGF-MUM 0.41--7.75 microgram/8 hr (n=11), PGE-MUM 0.60--11.39 microgram/8 hr.
Authors:
Y Aizawa; K Yamada; M Hata
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prostaglandins     Volume:  14     ISSN:  0090-6980     ISO Abbreviation:  Prostaglandins     Publication Date:  1977  
Date Detail:
Created Date:  1978-03-29     Completed Date:  1978-03-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0320271     Medline TA:  Prostaglandins     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1165-74     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Chromatography, Gel
Humans
Indomethacin / pharmacology
Prostaglandins E / urine*
Prostaglandins F / urine*
Radioisotope Dilution Technique / methods*
Chemical
Reg. No./Substance:
0/Prostaglandins E; 0/Prostaglandins F; 53-86-1/Indomethacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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