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Double filtration plasmapheresis and interferon combination therapy for chronic hepatitis C patients with genotype 1 and high viral load.
MedLine Citation:
PMID:  17573947     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
AIM: The efficacy and safety of double filtration plasmapheresis (DFPP) plus interferon (IFN) combination therapy were compared with those of IFN therapy alone in 193 chronic hepatitis C patients having a high hepatitis C virus ribonucleic acid load of difficult-to-treat genotype 1b.
METHODS: All patients received either interferon alpha-2b (IFN-alpha-2b) monotherapy or combination therapies with ribavirin and IFN-alpha-2b or pegylated interferon alpha-2b (PEG-IFN-alpha-2b). Each patient individually decided whether to receive concomitant DFPP. DFPP was immediately followed by IFN treatment, and up to five sessions were given during the first week.
RESULTS: Sixty patients decided to receive DFPP. In the DFPP plus PEG-IFN-alpha-2b therapy group (n = 30), viral load reduction at 4 weeks after the start of treatment was greater than innon-DFPP (n = 74) (2.47 vs 1.52, log, P = 0.010), and the sustained virus response was also higher (77.8% vs 50.0%), even in cases of re-treated patients (relapsers or non-responders to previous IFN therapies). Adverse events, mild and transient, were observed in 38.3% of all DFPP-treated patients.
CONCLUSION: DFPP plus IFN combination therapy produced a great reduction of viral load during the early stage of treatment and achieved a high sustained virus response, suggesting that this combination therapy may be a new modality for chronic hepatitis C patients at difficult-to-treat states.
Authors:
Kenji Fujiwara; Shuichi Kaneko; Shinichi Kakumu; Michio Sata; Shuhei Hige; Eiichi Tomita; Satoshi Mochida;
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Publication Detail:
Type:  Journal Article     Date:  2007-06-15
Journal Detail:
Title:  Hepatology research : the official journal of the Japan Society of Hepatology     Volume:  37     ISSN:  1386-6346     ISO Abbreviation:  Hepatol. Res.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-07-09     Completed Date:  2011-07-14     Revised Date:  2014-07-29    
Medline Journal Info:
Nlm Unique ID:  9711801     Medline TA:  Hepatol Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  701-10     Citation Subset:  -    
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