| Double filtration plasmapheresis and interferon combination therapy for chronic hepatitis C patients with genotype 1 and high viral load. | |
| | |
MedLine Citation:
|
PMID: 17573947 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
|
Aim: The efficacy and safety of double filtration plasmapheresis (DFPP) plus interferon (IFN) combination therapy were compared with those of IFN therapy alone in 193 chronic hepatitis C patients having a high hepatitis C virus ribonucleic acid load of difficult-to-treat genotype 1b. Methods: All patients received either interferon alpha-2b (IFN-alpha-2b) monotherapy or combination therapies with ribavirin and IFN-alpha-2b or pegylated interferon alpha-2b (PEG-IFN-alpha-2b). Each patient individually decided whether to receive concomitant DFPP. DFPP was immediately followed by IFN treatment, and up to five sessions were given during the first week. Results: Sixty patients decided to receive DFPP. In the DFPP plus PEG-IFN-alpha-2b therapy group (n = 30), viral load reduction at 4 weeks after the start of treatment was greater than innon-DFPP (n = 74) (2.47 vs 1.52, log, P = 0.010), and the sustained virus response was also higher (77.8% vs 50.0%), even in cases of re-treated patients (relapsers or non-responders to previous IFN therapies). Adverse events, mild and transient, were observed in 38.3% of all DFPP-treated patients. Conclusion: DFPP plus IFN combination therapy produced a great reduction of viral load during the early stage of treatment and achieved a high sustained virus response, suggesting that this combination therapy may be a new modality for chronic hepatitis C patients at difficult-to-treat states. |
| | |
Authors:
|
Kenji Fujiwara; Shuichi Kaneko; Shinichi Kakumu; Michio Sata; Shuhei Hige; Eiichi Tomita; Satoshi Mochida; |
Related Documents
:
|
19651007 - Response to combination therapy in hepatitis virus c genotype 2 and 3. 19617847 - Adult clinical and immunologic outcomes of the national antiretroviral treatment progra... 3168077 - Interferon in chronic active hepatitis b. preliminary results. 20453627 - Randomized controlled trial of trained patient-nominated treatment supporters providing... 20172547 - Fentanyl sparing effects of combined ketorolac and acetaminophen for outpatient inguina... 23296077 - Deep brain stimulation in children with dystonia: experience from a tertiary care center. |
Publication Detail:
|
Type: Journal Article Date: 2007-06-15 |
Journal Detail:
|
Title: Hepatology research : the official journal of the Japan Society of Hepatology Volume: 37 ISSN: 1386-6346 ISO Abbreviation: Hepatol. Res. Publication Date: 2007 Sep |
Date Detail:
|
Created Date: 2007-07-09 Completed Date: 2011-07-14 Revised Date: 2013-02-07 |
Medline Journal Info:
|
Nlm Unique ID: 9711801 Medline TA: Hepatol Res Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 701-10 Citation Subset: - |
Affiliation:
|
Yokohama Rosai Hospital, Yokohama, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: HFE C282Y gene variant is a risk factor for the progression to decompensated liver disease in chroni...
Next Document: Clinical significance of fatty liver associated with metabolic syndrome.