| Double esterase staining of the bone marrow contributes to lineage identification in a case of minimally differentiated acute myeloid leukaemia (AML M0). | |
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MedLine Citation:
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PMID: 10583335 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Minimally differentiated acute myeloid leukaemia (AML-M0) may pose difficulty in diagnosis since morphological criteria alone are not reliable. Other studies such as electron microscopy, immunocytochemistry and surface marker analysis are needed. The role of cytochemistry has been limited to the negative staining of blasts for Sudan Black B and myeloperoxidase. An abnormal morphology and cytochemistry of bone marrow maturing cells may indicate the myeloid nature of acute leukaemia. In this case of AML-M0, increased numbers of maturing and mature bone marrow granulocytic cells staining simultaneously for both specific and non-specific esterase (double esterase) are described. In acute leukaemia, this abnormal cytochemical finding seems to be specific for myeloid leukaemia and may be used as supplementary evidence of myeloid differentiation of morphologically undifferentiated blasts in cases of AML-M0. |
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Authors:
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M T Elghetany |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Clinical and laboratory haematology Volume: 21 ISSN: 0141-9854 ISO Abbreviation: Clin Lab Haematol Publication Date: 1999 Aug |
Date Detail:
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Created Date: 2000-05-25 Completed Date: 2000-05-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7907061 Medline TA: Clin Lab Haematol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 293-5 Citation Subset: IM |
Affiliation:
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Department of Pathology, University of Texas Medical Branch, Galveston, TX 77550-0743, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Antigens, CD / metabolism Bone Marrow Cells / chemistry, cytology*, immunology Cell Lineage* / immunology Diagnosis, Differential Esterases* Female Histocytochemistry Humans Leukemia, Myeloid / classification*, diagnosis*, pathology Middle Aged Staining and Labeling / methods |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; EC 3.1.-/Esterases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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