Document Detail


Double esterase staining of the bone marrow contributes to lineage identification in a case of minimally differentiated acute myeloid leukaemia (AML M0).
MedLine Citation:
PMID:  10583335     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Minimally differentiated acute myeloid leukaemia (AML-M0) may pose difficulty in diagnosis since morphological criteria alone are not reliable. Other studies such as electron microscopy, immunocytochemistry and surface marker analysis are needed. The role of cytochemistry has been limited to the negative staining of blasts for Sudan Black B and myeloperoxidase. An abnormal morphology and cytochemistry of bone marrow maturing cells may indicate the myeloid nature of acute leukaemia. In this case of AML-M0, increased numbers of maturing and mature bone marrow granulocytic cells staining simultaneously for both specific and non-specific esterase (double esterase) are described. In acute leukaemia, this abnormal cytochemical finding seems to be specific for myeloid leukaemia and may be used as supplementary evidence of myeloid differentiation of morphologically undifferentiated blasts in cases of AML-M0.
Authors:
M T Elghetany
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical and laboratory haematology     Volume:  21     ISSN:  0141-9854     ISO Abbreviation:  Clin Lab Haematol     Publication Date:  1999 Aug 
Date Detail:
Created Date:  2000-05-25     Completed Date:  2000-05-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7907061     Medline TA:  Clin Lab Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  293-5     Citation Subset:  IM    
Affiliation:
Department of Pathology, University of Texas Medical Branch, Galveston, TX 77550-0743, USA.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Antigens, CD / metabolism
Bone Marrow Cells / chemistry,  cytology*,  immunology
Cell Lineage* / immunology
Diagnosis, Differential
Esterases*
Female
Histocytochemistry
Humans
Leukemia, Myeloid / classification*,  diagnosis*,  pathology
Middle Aged
Staining and Labeling / methods
Chemical
Reg. No./Substance:
0/Antigens, CD; EC 3.1.-/Esterases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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