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Double embryo transfer gives good pregnancy-and live birth rates in poor responders with a modest increase in multiple birth rates. results from an observational study.
MedLine Citation:
PMID:  21446930     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective. The aim of this study was to compare pregnancy- and live birth rates in poor responders when transferring one or two embryos. Poor responders were defined as having four or less oocytes retrieved in combination with a high dose of gonadotrophins. Design. Retrospective, observational study. Setting. Reproductive Medicine, University Hospital. Methods and Sample. All fresh cycles, in total 5 351, performed during the years 2003-2008 were included, where 367 cycles were poor responders. Main outcome measures. Pregnancy-and live birth rates. Results. In the poor responders the live birth rates per oocyte pickup (OPU) and embryo transfer (ET) was 10.9% and 16.3% versus 23.9% and 27.7% in the normal responders (p=0.0001 and p=0.01). In the poor responders the live birth rates per single embryo transfer (SET) was 10.8% versus 27.8% per double embryo transfer (DET) (p=0.0014) and in normal responders 28.1% versus 26.6% (p=0.34). Multiple birth rates after DET were 9.1% in the poor responders and 25.6% in the normal responders. Conclusions. This study confirms that poor responders have overall lower live birth rates after IVF treatment compared to normal responders. The live birth rate after DET in poor responders was clinically and statistically significantly higher than after SET and with a modest increase in multiple birth rates. Thus, in poor responders, DET might be considered more often than in normal responders. SET should however be the first option among women stimulated with a low/normal dose of gonadotrophins irrespective of the number of retrieved oocytes.
Authors:
Ingunn Jonsdottir; Kersti Lundin; Christina Bergh
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-29
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  -     ISSN:  1600-0412     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The Authors AOGS© 2011 Nordic Federation of Societies of Obstetrics and Gynecology.
Affiliation:
Reproductive Medicine, Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, Sahlgrenska University Hospital, Göteborg University, SE-413 45 Göteborg, Sweden.
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