| Double-edged effects of neuropeptide substance P on repair of cutaneous trauma. | |
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MedLine Citation:
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PMID: 20412553 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To explore further the role of substance P (SP) in wound healing and scar formation, SP concentrations in wounds of scalded rats were assayed. Expressions of apoptosis-associated genes in fibroblasts cultured with SP were detected. SP concentrations in superficial wounds increased earlier than those in deep wounds. SP was associated with an increased proliferation and a decreased apoptosis of fibroblasts. It had a greater influence on keloid fibroblasts than on hypertrophic scar fibroblasts by elevating the expression of proliferating cell nuclear antigen and BCL-2 in fibroblasts. Spantide completely suppressed the effects of SP on hypertrophic scar fibroblasts, and partly inhibited its effects on keloid scar fibroblasts. SP may play an important role in wound healing by promoting wound fibroblast proliferation and inhibiting apoptosis. It may also participate in pathological scar formation by modulating the expression of apoptosis-associated genes. SP is postulated to play a dual role in wound repair. |
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Authors:
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Chen Jing; Wang Jia-Han; Zhuang Hong-Xing |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-15 |
Journal Detail:
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Title: Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society Volume: 18 ISSN: 1524-475X ISO Abbreviation: Wound Repair Regen Publication Date: 2010 May-Jun |
Date Detail:
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Created Date: 2010-06-24 Completed Date: 2010-10-13 Revised Date: 2011-01-11 |
Medline Journal Info:
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Nlm Unique ID: 9310939 Medline TA: Wound Repair Regen Country: United States |
Other Details:
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Languages: eng Pagination: 319-24 Citation Subset: IM |
Affiliation:
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Department of Burns Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China. chenjing_168@tom.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Animals Apoptosis / physiology Burns / physiopathology* Cell Proliferation Cicatrix, Hypertrophic / physiopathology Female Fibroblasts / physiology* Humans Keloid / physiopathology Male Middle Aged Rats Rats, Wistar Substance P / pharmacology, physiology* Wound Healing / drug effects, physiology* Young Adult |
| Chemical | |
Reg. No./Substance:
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33507-63-0/Substance P |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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