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Double-blinded randomized trial of preoperative antibiotics in midurethral sling procedures and review of the literature.
MedLine Citation:
PMID:  21789661     Owner:  NLM     Status:  Publisher    
INTRODUCTION AND HYPOTHESIS: The objective of this study was to determine if prophylactic antibiotic use before midurethral sling procedures reduces infectious complications. METHODS: In this double-blinded randomized trial, we compared infectious complications between women who received cefazolin and placebo before midurethral sling procedures. RESULTS: The study was halted due to low rate of infectious outcomes seen at the first scheduled interim analysis. We enrolled 29 women in the cefazolin group and 30 in the placebo group. Total follow-up was 6 months (3-24 months). The groups were similar at the baseline. There was no statistically significant difference between the cefazolin and placebo groups, respectively, with respect to wound infections [1 (3.3%) and 0 (0%)], mesh exposure [0 (0%) and 1 (3.5%)], and bacteriuria [3 (10%) and 1 (3.5%)]. CONCLUSION: Because infection rates are low in both cefazolin and placebo groups, omitting preoperative antibiotics for midurethral slings may be justified.
Oz Harmanli; Rebecca L Boyer; Stephen Metz; Elena Tunitsky; Keisha A Jones
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-26
Journal Detail:
Title:  International urogynecology journal and pelvic floor dysfunction     Volume:  -     ISSN:  1433-3023     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9514583     Medline TA:  Int Urogynecol J Pelvic Floor Dysfunct     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Obstetrics and Gynecology, Tufts University School of Medicine, Baystate Medical Center, 759 Chestnut Street, S-1681, Springfield, MA, 01199, USA,
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