| Double-blind trial of aspirin in patient receiving tranexamic acid for subarachnoid hemorrhage. | |
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MedLine Citation:
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PMID: 7102384 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Antifibrinolytic agents have been claimed to reduce the rebleed rate in patients with subarachnoid haemorrhage from intracranial aneurysms. However, these agents may in themselves increase the incidence of delayed cerebral ischaemia in these patients. We have used aspirin in an attempt to reduce the incidence of this complication. In a prospective, double-blind trial of aspirin against placebo, 53 patients with subarachnoid haemorrhage were all treated with the antifibrinolytic agent tranexamic acid. Twenty-seven patients received aspirin and 26 patients received placebo. The morbidity and mortality was similar in each group. A further breakdown into patients who had their aneurysms clipped at craniotomy (21 patients) similarly failed to show a more favourable outcome in either group. It is concluded that aspirin does not affect the outcome in patients with subarachnoid haemorrhage treated with tranexamic acid. |
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Authors:
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A D Mendelow; G Stockdill; A J Steers; J Hayes; F J Gillingham |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Acta neurochirurgica Volume: 62 ISSN: 0001-6268 ISO Abbreviation: Acta Neurochir (Wien) Publication Date: 1982 |
Date Detail:
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Created Date: 1982-09-24 Completed Date: 1982-09-24 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0151000 Medline TA: Acta Neurochir (Wien) Country: AUSTRIA |
Other Details:
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Languages: eng Pagination: 195-202 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiography Aphasia / etiology Aspirin / administration & dosage, therapeutic use* Double-Blind Method Female Hemiplegia / etiology Humans Intracranial Aneurysm / complications Male Subarachnoid Hemorrhage / complications, drug therapy*, etiology Tranexamic Acid / therapeutic use |
| Chemical | |
Reg. No./Substance:
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1197-18-8/Tranexamic Acid; 50-78-2/Aspirin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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