Document Detail

Double-blind trial of aspirin in patient receiving tranexamic acid for subarachnoid hemorrhage.
MedLine Citation:
PMID:  7102384     Owner:  NLM     Status:  MEDLINE    
Antifibrinolytic agents have been claimed to reduce the rebleed rate in patients with subarachnoid haemorrhage from intracranial aneurysms. However, these agents may in themselves increase the incidence of delayed cerebral ischaemia in these patients. We have used aspirin in an attempt to reduce the incidence of this complication. In a prospective, double-blind trial of aspirin against placebo, 53 patients with subarachnoid haemorrhage were all treated with the antifibrinolytic agent tranexamic acid. Twenty-seven patients received aspirin and 26 patients received placebo. The morbidity and mortality was similar in each group. A further breakdown into patients who had their aneurysms clipped at craniotomy (21 patients) similarly failed to show a more favourable outcome in either group. It is concluded that aspirin does not affect the outcome in patients with subarachnoid haemorrhage treated with tranexamic acid.
A D Mendelow; G Stockdill; A J Steers; J Hayes; F J Gillingham
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Acta neurochirurgica     Volume:  62     ISSN:  0001-6268     ISO Abbreviation:  Acta Neurochir (Wien)     Publication Date:  1982  
Date Detail:
Created Date:  1982-09-24     Completed Date:  1982-09-24     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0151000     Medline TA:  Acta Neurochir (Wien)     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  195-202     Citation Subset:  IM    
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MeSH Terms
Aphasia / etiology
Aspirin / administration & dosage,  therapeutic use*
Double-Blind Method
Hemiplegia / etiology
Intracranial Aneurysm / complications
Subarachnoid Hemorrhage / complications,  drug therapy*,  etiology
Tranexamic Acid / therapeutic use
Reg. No./Substance:
1197-18-8/Tranexamic Acid; 50-78-2/Aspirin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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