Document Detail

Double-blind randomized trial of ACTH versus dexamethasone versus methylprednisolone in multiple sclerosis bouts. Clinical, cerebrospinal fluid and neurophysiological results.
MedLine Citation:
PMID:  2540005     Owner:  NLM     Status:  MEDLINE    
30 patients with acute exacerbations of multiple sclerosis were treated by ACTH, dexamethasone or methylprednisolone in a double-blind randomized study. Clinical parameters were assessed; cerebrospinal fluid and neurophysiological parameters (visual- and brainstem-evoked potentials) were evaluated at the beginning and at the end of treatment. Dexamethasone was more effective than ACTH and 6-methylprednisolone in shortening bout duration. Neither CSF nor neurophysiological parameters were significantly affected by therapy.
C Milanese; L La Mantia; A Salmaggi; A Campi; M Eoli; V Scaioli; A Nespolo; F Corridori
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  European neurology     Volume:  29     ISSN:  0014-3022     ISO Abbreviation:  Eur. Neurol.     Publication Date:  1989  
Date Detail:
Created Date:  1989-06-01     Completed Date:  1989-06-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0150760     Medline TA:  Eur Neurol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  10-4     Citation Subset:  IM    
Department of Neurology, Istituto Neurologico C. Besta, Milano, Italy.
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MeSH Terms
Adrenocorticotropic Hormone / therapeutic use*
Dexamethasone / therapeutic use*
Dose-Response Relationship, Drug
Double-Blind Method
Evoked Potentials, Auditory
Evoked Potentials, Visual
Methylprednisolone / therapeutic use*
Multiple Sclerosis / drug therapy*,  physiopathology
Random Allocation
Reg. No./Substance:
50-02-2/Dexamethasone; 83-43-2/Methylprednisolone; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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