Document Detail

Double-blind, randomized, controlled trial of papaverine-containing infusions to prevent failure of arterial catheters in pediatric patients.
MedLine Citation:
PMID:  8504648     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To test the efficacy of the continuous infusion of papaverine-containing fluids into peripheral arterial catheters for reducing the risk of catheter failure. DESIGN: Prospective, double-blind, randomized, controlled trial. SETTING: Pediatric intensive care unit in a children's hospital. PATIENTS: A total of 239 children, aged 3 wks to 18 yrs who had an arterial catheter inserted for clinical purposes. INTERVENTIONS: Patients were randomized to receive either papaverine (60 mg/500 mL) or no additive, within the infused fluids. MEASUREMENTS AND MAIN RESULTS: Data about patient demographics and potential risk factors for arterial catheter failure were collected at the time of catheter insertion, throughout the life of the catheter, and at the time of catheter removal. Catheter failure was defined as an inability to draw blood from the catheter or loss of the arterial waveform. Overall, 35 (15%) subjects had catheter failure. The risk of catheter failure was lower in patients randomized to receive papaverine (eight [7%] of 115 vs. 27 [22%] of 124; chi-square = 5.2; p = .02), and the time until failure of the catheter was longer in the papaverine group (p = .02, log-rank test). This difference persisted when controlling for potentially confounding factors. CONCLUSION: In critically ill children, infusion of papaverine-containing fluids reduces the risk of failure of peripheral arterial catheters.
M J Heulitt; E A Farrington; T M O'Shea; S M Stoltzman; N B Srubar; D L Levin
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Critical care medicine     Volume:  21     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-07-08     Completed Date:  1993-07-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  825-9     Citation Subset:  AIM; IM    
Department of Pediatrics, Children's Medical Center, Dallas, TX.
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MeSH Terms
Catheterization, Peripheral*
Catheters, Indwelling*
Child, Preschool
Critical Illness
Double-Blind Method
Infant, Newborn
Papaverine / administration & dosage*,  adverse effects
Proportional Hazards Models
Prospective Studies
Risk Factors
Shock / therapy
Survival Analysis
Treatment Failure
Reg. No./Substance:
Comment In:
Crit Care Med. 1993 Jun;21(6):815   [PMID:  8504642 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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