Document Detail

Double-blind randomized controlled trial of isoxicam vs piroxicam in elderly patients with osteoarthritis of the hip and knee.
MedLine Citation:
PMID:  3620274     Owner:  NLM     Status:  MEDLINE    
1 Fifty-seven elderly patients with primary osteoarthritis of the hip and knee were entered into a double-blind, randomized, controlled parallel group trail to compare the efficacy and tolerability of isoxicam (maximum = 200 mg day-1) and piroxicam (maximum = 20 mg day-1). 2 Clinical assessments were made following a 1 week NSAID-free washout period and at biweekly intervals during the next 6 weeks of active treatment. 3 The majority of patients in both groups experienced a clinically important and statistically significant therapeutic response. 4 No statistically significant between-group differences were noted with respect to drug efficacy. 5 One patient was withdrawn from the piroxicam group because of lack of effect, but there were no such withdrawals from the isoxicam group. 6 Five patients were withdrawn from the piroxicam group because of adverse reactions compared to only one withdrawal from the isoxicam group. 7 This study indicates that isoxicam is an efficacious and well-tolerated once-daily NSAID for elderly patients with osteoarthritis.
N Bellamy; W W Buchanan; E Grace
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  22 Suppl 2     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1986  
Date Detail:
Created Date:  1987-09-28     Completed Date:  1987-09-28     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  149S-155S     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
Double-Blind Method
Middle Aged
Osteoarthritis / drug therapy*
Piroxicam / adverse effects,  analogs & derivatives*,  therapeutic use*
Random Allocation
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 34552-84-6/isoxicam; 36322-90-4/Piroxicam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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