Document Detail

Double-blind, randomised clinical assay to evaluate the efficacy of probiotics in preterm newborns weighing less than 1500 g in the prevention of necrotising enterocolitis.
MedLine Citation:
PMID:  22556209     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A randomised, double-blind clinical trial was undertaken in order to assess the effectiveness of probiotics in the prevention of necrotising enterocolitis (NEC) in newborns weighing <1500 g.
METHODS: We studied a group of 150 patients who were randomised in two groups after parental consent was obtained, to receive either a daily feeding supplementation with a multispecies probiotic (Lactobacillus acidophilus, Lactobacillus rhamnosus, Lactobacillus casei, Lactobacillus plantarum, Bifidobacteruim infantis, Streptococcus thermophillus) 1 g per day plus their regular feedings or to receive their regular feedings with nothing added (control group), over the period of January 2007 through June 2010. Clinicians in care of the infants were blinded to the group assignment.
RESULTS: The primary outcome was the development of NEC. Both groups were comparable, with no differences during hospitalisation, including the type of nutrition received. Blood cultures obtained from cases that developed sepsis did not reveal lactobacillus or Bifidobacteria growth. No differences were detected in terms of NEC risk reduction (RR: 0.54, 95% CI 0.21 to 1.39) although we did observe a clear trend in the reduction of NEC frequency in the studied cases: 6 (8%) versus 12 (16%) in the control group. When the combined risk of NEC or death was calculated as a post hoc analysis, we found a significantly lower risk (RR: 0.39, 95% CI 0.17 to 0.87) for the study group.
CONCLUSIONS: Probiotics may offer potential benefits for premature infants and are a promising strategy in the reduction of the risk of NEC in preterm newborns.
Luis Alberto Fernández-Carrocera; Aide Solis-Herrera; Marisol Cabanillas-Ayón; Rocío Beatriz Gallardo-Sarmiento; Carmina Sarisol García-Pérez; Rosalba Montaño-Rodríguez; Maria Olga Leticia Echániz-Aviles
Related Documents :
24158889 - Short-term morbidities of moderate and late preterm infants.
7300289 - Analysis of the sibship patterns of stutterers.
25388049 - The developmental and evolutionary origins of psychological essentialism lie in sortal ...
22375549 - Hydrocortisone and long-term outcomes in very low birth weight infants.
22752779 - Circulating endothelial progenitor cells in premature infants: is there an association ...
22475199 - Balloon atrial septostomy performed "out-of-hours": effects on the outcome.
9272929 - Neutral endopeptidase activity in newborn and adult rabbit tracheas.
1272119 - Complications of amniocentesis.
8333479 - Chorionic villus sampling in a patient who is an unusual carrier of hemophilia b.
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2012-05-03
Journal Detail:
Title:  Archives of disease in childhood. Fetal and neonatal edition     Volume:  98     ISSN:  1468-2052     ISO Abbreviation:  Arch. Dis. Child. Fetal Neonatal Ed.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-19     Completed Date:  2013-02-21     Revised Date:  2014-01-06    
Medline Journal Info:
Nlm Unique ID:  9501297     Medline TA:  Arch Dis Child Fetal Neonatal Ed     Country:  England    
Other Details:
Languages:  eng     Pagination:  F5-9     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Double-Blind Method
Enterocolitis, Necrotizing / prevention & control*
Infant, Newborn
Infant, Premature
Infant, Very Low Birth Weight*
Probiotics / therapeutic use*
Treatment Outcome
Comment In:
Evid Based Med. 2013 Dec;18(6):219-20   [PMID:  23604182 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Axillary temperature measurement during hypothermia treatment for neonatal hypoxic-ischaemic encepha...
Next Document:  Joint Hypothesis Testing and Gatekeeping Procedures for Studies with Multiple Endpoints.