| Double-blind placebo-controlled trial of oral cromolyn in children with atopic dermatitis and documented food hypersensitivity. | |
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MedLine Citation:
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PMID: 3123539 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ten children with challenge-proven egg hypersensitivity and atopic dermatitis were enrolled in a double-blind crossover trial of oral cromolyn sodium. After receiving up to 40 mg/kg/day of cromolyn or placebo for 1 week, patients underwent double-blind placebo-controlled oral food challenges. In the eight subjects who reacted to the food challenge, there was no significant difference in the amount of food allergen eliciting the positive response, the timing of onset until first subjective or objective symptoms developed, symptoms provoked, or the duration of the symptoms in either phase of the study. This study demonstrates no benefit in the treatment of children with atopic dermatitis and food hypersensitivity with oral cromolyn sodium. |
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Authors:
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A W Burks; H A Sampson |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of allergy and clinical immunology Volume: 81 ISSN: 0091-6749 ISO Abbreviation: J. Allergy Clin. Immunol. Publication Date: 1988 Feb |
Date Detail:
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Created Date: 1988-03-21 Completed Date: 1988-03-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1275002 Medline TA: J Allergy Clin Immunol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 417-23 Citation Subset: AIM; IM |
Affiliation:
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University of Arkansas, Fayetteville. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Allergens / administration & dosage Child Child, Preschool Clinical Trials as Topic* / methods Cromolyn Sodium / administration & dosage* Dermatitis, Atopic / complications, drug therapy* Double-Blind Method Eggs / adverse effects Female Food Hypersensitivity / complications, drug therapy* Humans Male Placebos |
| Grant Support | |
ID/Acronym/Agency:
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AI24439/AI/NIAID NIH HHS; RR-30/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Allergens; 0/Placebos; 15826-37-6/Cromolyn Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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