Document Detail


The acute effect of budesonide/formoterol in COPD: a multi-slice computed tomography and lung function study.
MedLine Citation:
PMID:  22183484     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification of chronic obstructive pulmonary disease (COPD) does not always match with other clinical disease descriptors such as exacerbation frequency and quality of life, indicating that forced expiratory volume in 1 s (FEV(1)) is not a perfect descriptor of the disease. The aim of this study was to find out whether changes in airway geometry after inhalation of the most commonly used inhalation therapy in severe COPD can more adequately be described with an image-based approach than with spirometry. 10 COPD GOLD stage III patients were assessed in a double-blind crossover study. Airway volumes were analysed using segmentation of multi-slice computed tomography (MSCT) images; airway resistance was determined using computational fluid dynamics (CFD). Distal airway volume significantly increased (p=0.011) in patients 4 h after receiving a budesonide/formoterol combination from 9.6±4.67 cm(3) to 10.14±4.81 cm(3). Also CFD-determined airway resistance significantly decreased (p=0.047) from 0.051±0.021 kPa·s·L(-1) to 0.043±0.019 kPa·s·L(-1). None of the lung function parameters showed a significant change. Only functional residual capacity (FRC) showed a trend to decline (p=0.056). Only the image-based parameters were able to predict the visit at which the combination product was administered. This study showed that imaging is a sensitive, complementary tool to describe changes in airway structure.
Authors:
Lieve A De Backer; Wim Vos; Jan De Backer; Cedric Van Holsbeke; Samir Vinchurkar; Wilfried De Backer
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2011-12-19
Journal Detail:
Title:  The European respiratory journal     Volume:  40     ISSN:  1399-3003     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-02     Completed Date:  2013-01-10     Revised Date:  2013-06-11    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  298-305     Citation Subset:  IM    
Affiliation:
Dept of Respiratory Medicine, Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Antwerp, Belgium. lieve.debacker@ua.ac.be
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MeSH Terms
Descriptor/Qualifier:
Aged
Bronchodilator Agents / therapeutic use*
Budesonide / therapeutic use*
Cross-Over Studies
Double-Blind Method
Ethanolamines / therapeutic use*
Female
Forced Expiratory Volume
Humans
Hydrodynamics
Image Processing, Computer-Assisted
Lung / pathology*
Male
Middle Aged
Multidetector Computed Tomography / methods*
Placebos
Predictive Value of Tests
Pressure
Pulmonary Disease, Chronic Obstructive / diagnosis,  drug therapy*
Spirometry / methods
Time Factors
Chemical
Reg. No./Substance:
0/Bronchodilator Agents; 0/Ethanolamines; 0/Placebos; 51333-22-3/Budesonide; 5ZZ84GCW8B/formoterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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