Document Detail


Double-blind parallel study of piroxicam versus indomethacin in the treatment of low back pain.
MedLine Citation:
PMID:  6236738     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Twenty-eight outpatients with chronic severe lumbar pain participated in a double-blind comparative trial on the clinical efficacy of orally administered piroxicam and indomethacin. Half of the patients received indomethacin, 25 mg t.i.d.; the other half received piroxicam 20 mg in the morning and a placebo at lunchtime and before dinner for six weeks. The patients were examined four times at two-week intervals for their capability to do daily tasks and for total lumbar mobility, forward bending, raising of both legs straight and the subjective assessment of pain. Side effects were recorded on a questionnaire and with laboratory tests. The overall results of both groups were similar. Thus, piroxicam, 20 mg daily, matches indomethacin, 25 mg t.i.d., in the treatment of low back pain. The side effects were slight. Treatment with indomethacin was stopped in one case (erythema and conjunctivitis). In the piroxicam group diarrhea, constipation, and pain in the tongue were reported, whereas in the indomethacin group gastrointestinal irritation and tiredness were typical symptoms.
Authors:
T Videman; K Osterman
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Annals of clinical research     Volume:  16     ISSN:  0003-4762     ISO Abbreviation:  Ann. Clin. Res.     Publication Date:  1984  
Date Detail:
Created Date:  1984-10-11     Completed Date:  1984-10-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0220042     Medline TA:  Ann Clin Res     Country:  FINLAND    
Other Details:
Languages:  eng     Pagination:  156-60     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Analgesics / adverse effects,  therapeutic use*
Back Pain / drug therapy*
Clinical Trials as Topic
Double-Blind Method
Female
Humans
Indomethacin / adverse effects,  therapeutic use*
Male
Middle Aged
Piroxicam
Sciatica / drug therapy
Thiazines / adverse effects,  therapeutic use*
Chemical
Reg. No./Substance:
0/Analgesics; 0/Thiazines; 36322-90-4/Piroxicam; 53-86-1/Indomethacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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