Document Detail


Double-blind, multicenter controlled trial comparing topical dimethyl sulfoxide and normal saline for treatment of hand ulcers in patients with systemic sclerosis.
MedLine Citation:
PMID:  3884019     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A prospective, randomized, double-blind trial compared topical therapy with 0.85% normal saline, 2% dimethyl sulfoxide (DMSO), and 70% DMSO for treatment of digital ulcers in 84 patients with systemic sclerosis. There were no statistically significant differences among the 3 treatment groups in the improvement in the total number of open ulcers, total surface area of open ulcers, average surface area per open ulcer, number of infected ulcers, number of inflamed ulcers, or patient pain assessment. While some patients improved during the study, improvement could not be attributed to a specific treatment. Over one-quarter of the patients treated with 70% DMSO were withdrawn for significant skin toxicity.
Authors:
H J Williams; D E Furst; S L Dahl; V D Steen; C Marks; E J Alpert; A M Henderson; C O Samuelson; J N Dreyfus; A Weinstein
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Arthritis and rheumatism     Volume:  28     ISSN:  0004-3591     ISO Abbreviation:  Arthritis Rheum.     Publication Date:  1985 Mar 
Date Detail:
Created Date:  1985-04-17     Completed Date:  1985-04-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370605     Medline TA:  Arthritis Rheum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  308-14     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Adolescent
Adult
Aged
Clinical Trials as Topic
Dimethyl Sulfoxide / administration & dosage,  therapeutic use*
Double-Blind Method
Hand Dermatoses / complications,  drug therapy*
Humans
Middle Aged
Scleroderma, Systemic / complications*
Skin Ulcer / complications,  drug therapy*
Sodium Chloride / therapeutic use*
Grant Support
ID/Acronym/Agency:
6-2218//PHS HHS; RR-64/RR/NCRR NIH HHS; RR-68/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
67-68-5/Dimethyl Sulfoxide; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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