| Double-blind, multicenter, active-controlled, randomized clinical trial to assess the safety and efficacy of orally administered nicorandil in patients with stable angina pectoris in China. | |
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MedLine Citation:
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PMID: 17526976 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The efficacy and safety of nicorandil were evaluated in Chinese patients with stable angina pectoris (AP) in a double-blind, multicenter, active-controlled, randomized clinical trial. METHODS AND RESULTS: After a 2-week washout period, 232 patients with stable AP were randomized to receive either nicorandil (5 mg tid; 115 patients) or isosorbide mononitrate (ISMN: 20 mg bid; 117 patients) for 2 weeks. Exercise capacity, number of weekly anginal attacks, nitroglycerin (NTG) consumption, and safety were evaluated. Nicorandil and ISMN significantly prolonged the time to 1 mm ST-segment depression in an exercise tolerance test. Both drugs improved the total exercise time and the time to onset of chest pain. There was no significant difference between the 2 groups. Nicorandil significantly decreased the number of anginal attacks and NTG consumption. ISMN decreased the number of anginal attacks significantly; however, there was no significance in NTG consumption, and the ratio of anginal attack reduction was at least 50% was significantly higher with nicorandil. Nicorandil was well tolerated and there was no safety profile difference compared with ISMN. Thus, nicorandil may have equivalent or better antianginal effect than ISMN. CONCLUSIONS: Nicorandil is beneficial as treatment for AP. |
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Authors:
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Wen-Ling Zhu; Yuan-Dong Shan; Jing-Xuan Guo; Jia-Ping Wei; Xin-Chun Yang; Tian-De Li; San-Qing Jia; Qing He; Jun-Zhu Chen; Zong-Gui Wu; Zhan-Quan Li; Kai You |
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Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 71 ISSN: 1346-9843 ISO Abbreviation: Circ. J. Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-05-28 Completed Date: 2007-12-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
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Languages: eng Pagination: 826-33 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Peking Union Medical College Hospital, Shuai Fu Yuan Wang Fu Jing, Beijing 100730, China. zhuwenling@263.net |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Aged Angina Pectoris / drug therapy* Anti-Arrhythmia Agents / administration & dosage* China Double-Blind Method Exercise Female Humans Isosorbide Dinitrate / administration & dosage, analogs & derivatives Male Middle Aged Nicorandil / administration & dosage* Nitroglycerin / administration & dosage Vasodilator Agents / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 0/Vasodilator Agents; 16051-77-7/isosorbide-5-mononitrate; 55-63-0/Nitroglycerin; 65141-46-0/Nicorandil; 87-33-2/Isosorbide Dinitrate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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