Document Detail

Double-blind factorial trial of prindolol and hydrochlorothiazide in hypertension.
MedLine Citation:
PMID:  781495     Owner:  NLM     Status:  MEDLINE    
The antihypertensive actions of the beta-adrenergic blocking agent, prindolol, and of the diuretic, hydrochlorothiazide, were analysed in a double-blind randomized 2 X 2 factorial trial in 16 patients. There were four eight-week phases in which patients received prindolol alone, hydrochlorothiazide alone, prindolol plus hydrochlorothiazide in combination, and no treatment. Both drugs were given in fixed doses: prindolol, 10 mg three times per day; hydrochlorothiazide, 50 mg per day. Blood pressure was measured weekly, alternately at the outpatient clinic and at home. Supine mean arterial pressure (MAP) in resting patients fell from 127 mm Hg in the placebo phase to 117 mm Hg with hydrochlorothiazide alone, 116 mm Hg with prindolol alone, and 111 mm Hg with the combination of prindolol and hydrochlorothiazide. (The standard error of difference between treatments was +/-3-58). A mean factorial effect of -7 mm Hg for hydrochlorothiazide (P less than 0-01) and -8 mm Hg for prindolol (P less than 0-01) was obtained, and the two drugs acted in an additive manner. The effects on standing blood pressure in resting patients were similar. No serious side effects were noted.
J P Chalmers; P I Korner; D J Tiller; A J Bune; J D Steiner; M J West; L M Wing; J F Uther
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Medical journal of Australia     Volume:  1     ISSN:  0025-729X     ISO Abbreviation:  Med. J. Aust.     Publication Date:  1976 May 
Date Detail:
Created Date:  1976-10-02     Completed Date:  1976-10-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0400714     Medline TA:  Med J Aust     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  650-3     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Clinical Trials as Topic
Depression, Chemical
Drug Therapy, Combination
Hydrochlorothiazide / adverse effects,  pharmacology,  therapeutic use*
Hypertension / drug therapy*,  physiopathology
Middle Aged
Pindolol / adverse effects,  pharmacology,  therapeutic use*
Reg. No./Substance:
0/Placebos; 13523-86-9/Pindolol; 58-93-5/Hydrochlorothiazide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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