| Double-blind evaluation of domperidone in acute vomiting and dyspeptic disorders. | |
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MedLine Citation:
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PMID: 7014284 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The anti-emetic effects of domperidone were evaluated under double-blind conditions in twenty-four patients with acute vomiting randomly assigned to treatment either with 10 mg i.m. domperidone (six female, five males) or with placebo (seven females, six males). The therapeutic results were better with domperidone and the differences from placebo were statistically significant (p less than 0.02). In a second randomized, crossover, double-blind trial, domperidone (10 mg t.i.d.) evaluated according to a nine-symptom rating scale, in eighteen dyspeptic patients, proved significantly more effective than placebo. The duration of treatment was 6 weeks and the drugs were crossed-over after 3 weeks. The difference between the two groups was most marked during the second phase of the trial. No side-effects were reported. |
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Authors:
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I Agorastos; N P Zissis; I Kaprinis; G Goulis |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: The Journal of international medical research Volume: 9 ISSN: 0300-0605 ISO Abbreviation: J. Int. Med. Res. Publication Date: 1981 |
Date Detail:
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Created Date: 1981-07-09 Completed Date: 1981-07-09 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0346411 Medline TA: J Int Med Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 143-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Benzimidazoles / therapeutic use* Clinical Trials as Topic Domperidone Double-Blind Method Dyspepsia / drug therapy* Female Humans Male Middle Aged Piperidines / therapeutic use* Vomiting / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Benzimidazoles; 0/Piperidines; 57808-66-9/Domperidone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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