Document Detail


Double-blind evaluation of domperidone in acute vomiting and dyspeptic disorders.
MedLine Citation:
PMID:  7014284     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The anti-emetic effects of domperidone were evaluated under double-blind conditions in twenty-four patients with acute vomiting randomly assigned to treatment either with 10 mg i.m. domperidone (six female, five males) or with placebo (seven females, six males). The therapeutic results were better with domperidone and the differences from placebo were statistically significant (p less than 0.02). In a second randomized, crossover, double-blind trial, domperidone (10 mg t.i.d.) evaluated according to a nine-symptom rating scale, in eighteen dyspeptic patients, proved significantly more effective than placebo. The duration of treatment was 6 weeks and the drugs were crossed-over after 3 weeks. The difference between the two groups was most marked during the second phase of the trial. No side-effects were reported.
Authors:
I Agorastos; N P Zissis; I Kaprinis; G Goulis
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Journal of international medical research     Volume:  9     ISSN:  0300-0605     ISO Abbreviation:  J. Int. Med. Res.     Publication Date:  1981  
Date Detail:
Created Date:  1981-07-09     Completed Date:  1981-07-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0346411     Medline TA:  J Int Med Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  143-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Benzimidazoles / therapeutic use*
Clinical Trials as Topic
Domperidone
Double-Blind Method
Dyspepsia / drug therapy*
Female
Humans
Male
Middle Aged
Piperidines / therapeutic use*
Vomiting / drug therapy*
Chemical
Reg. No./Substance:
0/Benzimidazoles; 0/Piperidines; 57808-66-9/Domperidone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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