| Double-blind crossover randomized trial of intravenously administered verapamil. Its use for atrial fibrillation and flutter following open heart surgery. | |
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MedLine Citation:
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PMID: 6703818 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fourteen patients with onset of atrial fibrillation (11) or flutter (three) and ventricular rate over 120 beats per minute following cardiac surgery were treated with intravenous (IV) doses of verapamil hydrochloride or placebo in a double-blind crossover protocol. Patients with poor left ventricular function, hypotension, atrioventricular block, and taking beta-blockers and disopyramide were excluded. The dosages were 0.075 mg/kg and 0.15 mg/kg given 15 minutes apart, with termination of study on achieving an end point (conversion to sinus rhythm or slowing of ventricular rate to below 100 beats per minute). None reached the end point with placebo but all with verapamil. Baseline ventricular rate was 144 +/- 20 beats per minute, after placebo 143 +/- 16 beats per minute, and after verapamil 89 +/- 7 beats per minute (mean +/- SD). Thus, IV verapamil briefly slows the ventricular rate of atrial tachyarrhythmias following cardiac surgery. |
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Authors:
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M H Hwang; J Danoviz; I Pacold; N Rad; H S Loeb; R M Gunnar |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Archives of internal medicine Volume: 144 ISSN: 0003-9926 ISO Abbreviation: Arch. Intern. Med. Publication Date: 1984 Mar |
Date Detail:
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Created Date: 1984-03-27 Completed Date: 1984-03-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372440 Medline TA: Arch Intern Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 491-4 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Atrial Fibrillation / drug therapy* Blood Pressure / drug effects Double-Blind Method Drug Evaluation Electrophysiology Female Heart Rate / drug effects Humans Injections, Intravenous Male Middle Aged Postoperative Period Random Allocation Verapamil / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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52-53-9/Verapamil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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