Document Detail


Double blind cross-over trial comparing fenbufen and acetylsalicylic acid in rheumatoid arthritis.
MedLine Citation:
PMID:  7192125     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
25 out-patients with active classical or definite adult-onset rheumatoid arthritis were enrolled in a 4-week randomized, two-period double-blind cross-over study comparing gamma-oxo(1,1'-biphenyl)-4-butanoic acid (fenbufen) (1000 mg/d) and acetylsalicylic acid (ASA) (3600 mg/d). Only patients with active, flaring disease, off antiinflammatory drugs, were admitted into this study. Significant mean improvement from baseline was seen with both fenbufen and ASA after two weeks of treatment. There were no statistically significant differences between the degree of improvement from baseline between fenbufen and ASA. However, there were significant differences in patient tolerance of the two medications with more patients reporting adverse experiences with ASA than with fenbufen. The differences between treatments were statistically significant for side effects graded as moderate or severe with 6 patients experiencing drug-related side effects on ASA compared to none on fenbufen.
Authors:
L G Anderson; P R Bina
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Arzneimittel-Forschung     Volume:  30     ISSN:  0004-4172     ISO Abbreviation:  Arzneimittelforschung     Publication Date:  1980  
Date Detail:
Created Date:  1981-01-29     Completed Date:  1981-01-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372660     Medline TA:  Arzneimittelforschung     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  735-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Anti-Inflammatory Agents / adverse effects,  therapeutic use*
Arthritis, Rheumatoid / drug therapy*,  physiopathology
Aspirin / adverse effects,  therapeutic use*
Biphenyl Compounds / therapeutic use
Double-Blind Method
Drug Evaluation
Female
Humans
Male
Middle Aged
Phenylbutyrates*
Propionates / therapeutic use*
Propionic Acids / therapeutic use*
Time Factors
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Biphenyl Compounds; 0/Phenylbutyrates; 0/Propionates; 0/Propionic Acids; 36330-85-5/fenbufen; 50-78-2/Aspirin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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