Document Detail

Double-blind controlled investigation of bilateral prefrontal transcranial magnetic stimulation for the treatment of resistant major depression.
MedLine Citation:
PMID:  12537034     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The efficacy and safety of bilateral prefrontal repetitive transcranial magnetic stimulation (rTMS) for treating resistant major depression were examined in a double-blind, placebo-controlled study. METHOD: Nineteen medication-resistant depressed subjects were randomly assigned to 3 weeks of active or sham rTMS. Effects on mood and neuropsychological function were assessed. RESULTS: Both groups improved significantly in mood over the 3 weeks, but there was no significant difference between active and sham treatments. There were no significant neuropsychological effects. CONCLUSIONS: Bilateral rTMS was not superior to sham in treating resistant depression in this pilot study, but caused no neuropsychological impairment.
C K Loo; P B Mitchell; V M Croker; G S Malhi; W Wen; S C Gandevia; P S Sachdev
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychological medicine     Volume:  33     ISSN:  0033-2917     ISO Abbreviation:  Psychol Med     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-01-22     Completed Date:  2003-04-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254142     Medline TA:  Psychol Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  33-40     Citation Subset:  IM    
Department of Psychiatry, Mood Disorders Unit, Black Dog Institute and Neuropsychiatric Institute, Prince of Wales Hospital, School of Psychiatry, University of New South Wales, Randwick, Australia.
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MeSH Terms
Antidepressive Agents / therapeutic use
Depressive Disorder, Major / physiopathology,  psychology,  therapy*
Double-Blind Method
Drug Resistance
Middle Aged
Neuropsychological Tests
Physical Stimulation
Prefrontal Cortex / physiopathology*
Psychiatric Status Rating Scales
Transcranial Magnetic Stimulation / therapeutic use*
Treatment Outcome
Reg. No./Substance:
0/Antidepressive Agents
Comment In:
Psychol Med. 2003 Jan;33(1):7-13   [PMID:  12537031 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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