Document Detail

Double-blind comparison of rectally administered diazepam to placebo for pediatric sedation: the cardiovascular response.
MedLine Citation:
PMID:  3868306     Owner:  NLM     Status:  MEDLINE    
The sedative and cardiovascular effects of rectally administered diazepam (0.6 mg/kg) were compared to placebo in uncooperative children who required sedation during dental treatment. Twelve healthy preschool children, who required amalgam restorations, were treated during two standardized restorative appointments in a double-blind, crossover study. Blood pressure and pulse were obtained during four specified intervals during the appointment. The behavior of the children during the treatment visits was videotaped and later statistically analyzed using a kinesics/vocalization instrument. Behavioral ratings of cooperation were significantly improved during the treatment visit following diazepam. All interfering bodily movements, patient vocalizations and operator commands for the diazepam group were reduced significantly (p≤0.0001). No significant differences were observed for noninterfering behavioral response. Rectally administered diazepam did not alter blood pressure or pulse significantly in these sedated children when compared to the placebo. These findings indicate that rectal diazepam is an effective sedative agent with minimal effect on the cardiovascular system for the management of the young pediatric dental patient.
C M Flaitz; A J Nowak; M J Hicks
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Anesthesia progress     Volume:  32     ISSN:  0003-3006     ISO Abbreviation:  Anesth Prog     Publication Date:    1985 Nov-Dec
Date Detail:
Created Date:  1986-04-24     Completed Date:  1986-04-24     Revised Date:  2010-10-26    
Medline Journal Info:
Nlm Unique ID:  0043533     Medline TA:  Anesth Prog     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  232-6     Citation Subset:  D    
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MeSH Terms
Anesthesia, Dental*
Anesthesia, Rectal*
Child, Preschool
Diazepam / administration & dosage*,  pharmacology
Double-Blind Method
Heart / drug effects*
Hemodynamics / drug effects
Reg. No./Substance:
0/Placebos; 439-14-5/Diazepam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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