Document Detail

Double-blind comparison of metaproterenol and isoetharine-phenylephrine solutions in intermittent positive pressure breathing in bronchospastic conditions.
MedLine Citation:
PMID:  7000452     Owner:  NLM     Status:  MEDLINE    
A 5 percent solution of metaproterenol sulfate (Alupent) and a fixed-combination solution of isoetharine and phenylephrine were compared in a single-dose double-blind study in a total of 27 patients with reversible bronchospastic disease. The patients were assigned to parallel groups for treatment and received the usual dose of 0.3 ml of metaproterenol and 0.5 ml of the isoetharine-phenylephrine solution via equipment for intermittent positive-pressure breathing. Tests of pulmonary function, blood pressure, and pulse rate were performed before the treatment and at intervals of 30 minutes to six hours after administration. The duration of effect (defined as an increase over baseline in the forced expiratory volume in one second [FEV1] of at least 15 percent) of metaproterenol averaged four hours, as compared with one hour for the reference solution. The overall response of FEV1 to metaproterenol was significantly (P = 0.01) superior to the response to the isoetharine-phenylephrine solution. Metaproterenol also surpassed the reference drug in terms of increases in the mean forced expiratory flow during the middle half of the forced vital capacity (FEF-25-75%) to a degree approaching statistical significance. Changes in blood pressure and pulse rate were clinically insignificant with both drugs, and the total number of adverse experiences was substantially the same with both solutions.
J B Riker; L G Cacace
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Chest     Volume:  78     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1980 Nov 
Date Detail:
Created Date:  1981-01-29     Completed Date:  1981-01-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  723-5     Citation Subset:  AIM; IM    
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MeSH Terms
Asthma / therapy
Blood Gas Analysis
Bronchial Spasm / therapy*
Bronchodilator Agents / therapeutic use*
Clinical Trials as Topic
Double-Blind Method
Drug Combinations
Intermittent Positive-Pressure Breathing*
Isoetharine / therapeutic use
Middle Aged
Orciprenaline / therapeutic use
Phenylephrine / therapeutic use
Positive-Pressure Respiration*
Respiratory Function Tests
Reg. No./Substance:
0/Bronchodilator Agents; 0/Drug Combinations; 530-08-5/Isoetharine; 586-06-1/Orciprenaline; 59-42-7/Phenylephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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