| Double-blind comparison of azelaic acid 20% cream and its vehicle in treatment of papulo-pustular rosacea. | |
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MedLine Citation:
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PMID: 10598760 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous investigations have indicated that topical azelaic acid has beneficial effects in rosacea. This 3-month randomized, double-blind, multicentre study compared the efficacy and safety of azelaic acid 20% cream with its vehicle, in the treatment of papulo-pustular rosacea. A total of 116 patients were enrolled in the study and medication was applied twice daily. Azelaic acid cream produced significantly greater mean reductions in total inflammatory lesions than did vehicle (azelaic acid: 73.4%; vehicle: 50.6%; (p = 0.011), and erythema severity score (azelaic acid: 47.9%; vehicle: 37.9%; (p = 0.031). Azelaic acid cream treatment also resulted in significantly more favourable overall improvements than vehicle in both physician (p = 0.020) and patient ratings (p = 0.042). Neither azelaic acid cream nor vehicle produced any clinically relevant improvement in telangiectasia. Local adverse events were transient and mainly mild or moderate, and rates were similar for azelaic acid cream (39.5%) and vehicle (38.5%). Burning was the symptom most frequently reported. More than 90% of patients rated the overall local tolerability of their treatment as good or acceptable. In conclusion, azelaic acid 20% cream is effective and well tolerated in the treatment of papulo-pustular rosacea. |
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Authors:
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R Bjerke; O Fyrand; K Graupe |
Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
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Title: Acta dermato-venereologica Volume: 79 ISSN: 0001-5555 ISO Abbreviation: Acta Derm. Venereol. Publication Date: 1999 Nov |
Date Detail:
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Created Date: 2000-01-21 Completed Date: 2000-01-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370310 Medline TA: Acta Derm Venereol Country: NORWAY |
Other Details:
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Languages: eng Pagination: 456-9 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Ullevål Hospital, Oslo, Norway. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Cutaneous Adolescent Adult Dermatologic Agents / administration & dosage* Dicarboxylic Acids / administration & dosage* Double-Blind Method Female Follow-Up Studies Humans Male Middle Aged Reference Values Rosacea / drug therapy*, pathology Severity of Illness Index Statistics, Nonparametric Treatment Outcome Vehicles / administration & dosage |
| Chemical | |
Reg. No./Substance:
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0/Dermatologic Agents; 0/Dicarboxylic Acids; 0/Vehicles; 123-99-9/azelaic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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