| Double-blind comparative clinical trial of pimozide and chlorpromazine in mania. A test of the dopamine hypothesis. | |
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MedLine Citation:
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PMID: 7051755 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pimozide (PMZ), a relatively specific dopamine (DA) receptor blocking drug, was compared to chlorpromazine (CPZ) in a double-blind, between-patient clinical trial in mania. The trial lasted 14 days. Twenty-three patients who fulfilled Feighner's criteria for mania entered the trial (one patient entering on two separate occasions). Both drugs led to clinical improvement, with a significant effect being noted within 24 hours. According to one of the two rating scales used, initial improvement was greater with chlorpromazine, probably due to its greater sedative effect. By 7 days both drugs were equally effective. Sedative side effects were more frequent in patients on CPZ; extrapyramidal side effects were more frequent with PMZ. The finding that the relatively specific DA receptor blocking drug PMZ was as effective as CPZ in the treatment of mania is consistent with the view that hyperactivity of central DA pathways is involved in the pathogenesis of this condition. |
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Authors:
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J Cookson; T Silverstone; B Wells |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta psychiatrica Scandinavica Volume: 64 ISSN: 0001-690X ISO Abbreviation: Acta Psychiatr Scand Publication Date: 1981 Nov |
Date Detail:
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Created Date: 1982-10-21 Completed Date: 1982-10-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370364 Medline TA: Acta Psychiatr Scand Country: DENMARK |
Other Details:
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Languages: eng Pagination: 381-97 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Affective Disorders, Psychotic / drug therapy* Aged Bipolar Disorder / drug therapy* Chlorpromazine / therapeutic use* Clinical Trials as Topic Double-Blind Method Female Humans Male Middle Aged Pimozide / therapeutic use* Psychiatric Status Rating Scales Receptors, Dopamine / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Dopamine; 2062-78-4/Pimozide; 50-53-3/Chlorpromazine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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