| Double-blind clinical trial on gastroduodenal ulcer healing with prostaglandin E2 analogues. | |
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MedLine Citation:
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PMID: 330353 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Seventy-seven patients with gastroduodenal ulcer were treated with two methyl-prostaglandin E2 analogues, m-PGE2, in a double-blind clinical trial. Each of three groups was given 15 S-15 methyl PGE2 methyl ester, 15 R-15 methyl PGE2 methyl ester, and placebo, respectively. Both forms of m-PGE2 analogues appeared to reduce gastric acid secretion, to shorten ulcer healing, and also to produce some side-effects, form 'S' being the more potent. Prompt healing of the ulcer with these agents did not prevent the recurrence of the disease. As the serum gastrin response to a meal after m-PGE2 administration was not reduced, this agent seems directly to affect oxynthic cells. |
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Authors:
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K Gibiński; J Rybicka; E Mikoś; A Nowak |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Gut Volume: 18 ISSN: 0017-5749 ISO Abbreviation: Gut Publication Date: 1977 Aug |
Date Detail:
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Created Date: 1977-10-31 Completed Date: 1977-10-31 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2985108R Medline TA: Gut Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 636-9 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Clinical Trials as Topic Double-Blind Method Gastric Juice / secretion Humans Male Middle Aged Peptic Ulcer / drug therapy* Prostaglandins E / administration & dosage, therapeutic use* Prostaglandins, Synthetic |
| Chemical | |
Reg. No./Substance:
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0/Prostaglandins E; 0/Prostaglandins, Synthetic |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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