Document Detail


Dosimetry of a radioactive coronary balloon dilatation catheter for treatment of neointimal hyperplasia.
MedLine Citation:
PMID:  8946374     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent reports suggest that intraluminal irradiation of coronary arteries in conjunction with balloon angioplasty reduces proliferation of smooth muscle cells and neointima formation, thereby inhibiting restenosis. One possible irradiation technique is to inflate the balloon dilitation catheter with a radioactive solution. This has advantages over other proposed irradiation procedures, in that accurate source positioning and uniform dose to the vessel wall are assured. Several high-energy beta-minus emitters may be suitable for this application. We present experimental measurements and analytical calculations of the dose distribution around a 3-mm-diam by 20-mm-long balloon filled with 90Y-chloride solution. The dose rate at the surface of the balloon is approximately 0.14 cGy/s per mCi/ml (3.78 x 10(-11) Gy/s per Bq/ml), with the dose decreasing to 53% at 0.5 mm, and < 5% at 3.5-mm radial distance. 90Y and other possible isotopes are currently available at specific concentrations > or = 50 mCi/ml (1.85 x 10(9) Bq/ml), which enables the delivery of 20 Gy in less than 5 min. The dosimetric and radiation safety advantages of this system warrant further feasibility studies. Issues of concern include incorporating the beta-emitter into a suitable chemical form, and assessing organ and whole body doses in the (< 1 in 10(3)) event of balloon failure.
Authors:
H I Amols; L E Reinstein; J Weinberger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical physics     Volume:  23     ISSN:  0094-2405     ISO Abbreviation:  Med Phys     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1997-03-07     Completed Date:  1997-03-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0425746     Medline TA:  Med Phys     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1783-8     Citation Subset:  IM    
Affiliation:
Columbia University, Department of Radiation Oncology, New York, New York 10032, USA.
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MeSH Terms
Descriptor/Qualifier:
Angioplasty, Transluminal, Percutaneous Coronary* / instrumentation
Brachytherapy / instrumentation*,  methods
Combined Modality Therapy
Coronary Disease / radiotherapy,  therapy*
Coronary Vessels / pathology*,  radiation effects
Humans
Hyperplasia
Muscle, Smooth, Vascular / pathology,  radiation effects
Recurrence
Tunica Intima / pathology*,  radiation effects
Yttrium Radioisotopes / therapeutic use*
Chemical
Reg. No./Substance:
0/Yttrium Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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