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Dosimetry of a 238Pu-based {alpha}-Particle Irradiator and Its Biological Application in a Study of the Bystander Effect.
MedLine Citation:
PMID:  21737630     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
A better understanding of the non-targeted (bystander) effects of radiation may have important implications with regards to radiation risk assessment, radiation protection, and targeted cancer therapy. In the present study, the direct and bystander effects of α-particle irradiation in immortalized human fibroblasts (F11hTERT) and breast cancer cells (MCF-7) was investigated. To ensure a more accurate dose delivery to these different cell lines, an existing (238)Pu α-particle irradiator was improved by the addition of a collimator and the development of an analytical equation for calculation of the radiation dose to cells. The mean dose rate and α-particle fluence were calculated for each cell line by taking into consideration the size of their nuclei. Bystander effect experiments were performed by transferring medium from irradiated to unirradiated cells and by measuring micronucleus formation in the cells. Both the immortalized human fibroblasts and the breast cancer cells displayed a bystander effect. In conclusion, the broad-beam α-particle irradiator improved in this study represents a useful tool in the investigation of direct and non-targeted effects of α-particle radiation.
Authors:
Jostein Dahle; Erta Kalanxhi; Nikolai Tisnek
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anticancer research     Volume:  31     ISSN:  1791-7530     ISO Abbreviation:  Anticancer Res.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-07-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  2113-20     Citation Subset:  IM    
Affiliation:
Department of Radiation Biology, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway. jostein.dahle@rr-research.no.
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