Document Detail

Dosimetric impact of systematic MLC positional errors on step and shoot IMRT for prostate cancer: a planning study.
MedLine Citation:
PMID:  21409437     Owner:  NLM     Status:  Publisher    
The positional accuracy of multileaf collimators (MLC) is crucial in ensuring precise delivery of intensity-modulated radiotherapy (IMRT). The aim of this planning study was to investigate the dosimetric impact of systematic MLC positional errors on step and shoot IMRT of prostate cancer. A total of 12 perturbations of MLC leaf banks were introduced to six prostate IMRT treatment plans to simulate MLC systematic positional errors. Dose volume histograms (DVHs) were generated for the extraction of dose endpoint parameters. Plans were evaluated in terms of changes to the defined endpoint dose parameters, conformity index (CI) and healthy tissue avoidance (HTA) to planning target volume (PTV), rectum and bladder. Negative perturbations of MLC had been found to produce greater changes to endpoint dose parameters than positive perturbations of MLC (p < 0.01). Negative and positive asynchronised MLC perturbations of -1 mm resulted in median changes in D(95) of -1.2 and 0.9% respectively. Negative and positive synchronised MLC perturbations of 1 mm in one direction resulted in median changes in D(95) of -2.3 and 1.8% respectively. Doses to rectum were generally more sensitive to systematic MLC errors compared to bladder (p < 0.01). Negative and positive synchronised MLC perturbations of 1 mm in one direction resulted in median changes in endpoint dose parameters of rectum and bladder from 1.0 to 2.5%. Maximum reduction of -4.4 and -7.3% were recorded for conformity index (CI) and healthy tissue avoidance (HTA) respectively due to synchronised MLC perturbation of 1 mm. MLC errors resulted in dosimetric changes in IMRT plans for prostate.
N M Ung; C S Harper; L Wee
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-16
Journal Detail:
Title:  Australasian physical & engineering sciences in medicine / supported by the Australasian College of Physical Scientists in Medicine and the Australasian Association of Physical Sciences in Medicine     Volume:  -     ISSN:  0158-9938     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8208130     Medline TA:  Australas Phys Eng Sci Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
School of Physics, The University of Western Australia, 35 Stirling Highway, Crawley, WA, 6009, Australia,
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