Document Detail

Dosimetric impact of post-operative seroma reduction during radiotherapy after breast-conserving surgery.
MedLine Citation:
PMID:  21497929     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Three boost radiotherapy (RT) techniques were compared to evaluate the dosimetric effect of seroma reduction during RT after breast-conserving surgery (BCS).
MATERIALS AND METHODS: Twenty-one patients who developed seroma after BCS were included. Each patient underwent three CT scans: one week before RT (CT(-1)), in the third (CT(3)) and fifth (CT(5)) week of RT. For each patient, three plans were generated. (1) SEQ: whole breast irradiation planned on CT(-1,) sequential boost planned on CT(5), (2) SIB: simultaneous integrated boost planned on CT(-1), (3) SIB adaptive radiation therapy (SIB-ART): planned on CT(-1) and re-planned on CT(3). Irradiated volumes, mean lung (MLD) and maximum heart dose (HD(max)) were projected and compared on CT(5).
RESULTS: On average 62% seroma reduction during RT was observed. Volumes receiving ≥ 107% of prescribed whole breast dose were significantly smaller with SIB-ART compared to SEQ and SIB. The undesired volume receiving ≥ 95% of prescribed total dose was also significantly smaller with SIB-ART. For SEQ, SIB-ART and SIB, respectively, small but significant differences were found in MLD (4.2 vs. 4.6 vs. 4.7 Gy) and in HD(max) for patients with left-sided breast cancer (39.9 vs. 35.8 vs. 36.9 Gy).
CONCLUSIONS: This study demonstrates a dosimetric advantage for patients with seroma when simultaneous integrated boost is used with re-planning halfway through treatment.
Tanja Alderliesten; Suzanne den Hollander; Tzu-I Jonathan Yang; Paula H M Elkhuizen; Anke M van Mourik; Coen Hurkmans; Peter Remeijer; Corine van Vliet-Vroegindeweij
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-04-16
Journal Detail:
Title:  Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology     Volume:  100     ISSN:  1879-0887     ISO Abbreviation:  Radiother Oncol     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-09-02     Completed Date:  2011-12-29     Revised Date:  2012-03-08    
Medline Journal Info:
Nlm Unique ID:  8407192     Medline TA:  Radiother Oncol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  265-70     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Department of Radiation Oncology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
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MeSH Terms
Aged, 80 and over
Breast Neoplasms / radiotherapy*,  surgery
Mastectomy, Segmental*
Middle Aged
Postoperative Complications / prevention & control*
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted
Retrospective Studies
Seroma / prevention & control*
Tomography, X-Ray Computed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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