| Dosimetric impact of online correction via cone-beam CT-based image guidance for stereotactic lung radiotherapy. | |
| | |
MedLine Citation:
|
PMID: 20646857 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: To evaluate the dosimetric impact of online cone-beam computed tomography (CBCT) guided correction in lung stereotactic body radiation therapy (SBRT). METHODS AND MATERIALS: Twenty planning and 162 CBCT images from 20 patients undergoing lung SBRT were analyzed. The precorrection CBCT (CBCT after patient setup, no couch correction) was registered to planning CT using soft tissue; couch shift was applied, with a second CBCT for verification (postcorrection CBCT). Targets and normal structures were delineated on CBCTs: gross tumor volume (GTV), clinical target volume (CTV), cord, esophagus, lung, proximal bronchial tree, and aorta. Dose distributions on all organs manifested on each CBCT were compared with those planned on the CT. RESULTS: Without CBCT guided target position correction, target dose reduced with respect to treatment plan. Mean and standard deviation of treatment dose discrepancy from the plan were -3.2% (4.9%), -2.1% (4.4%), -6.1% (10.7%), and -3.5% (7%) for GTV D(99%), GTV D(95%), CTV D(99%), and CTV D(95%), respectively. With CBCT correction, the results were -0.4% (2.6%), 0.1% (1.7%), -0.3% (4.2%), and 0.5% (3%). Mean and standard deviation of the difference in normal organ maximum dose were 2.2% (6.5%) before correction and 2.4% (5.9%) after correction for esophagus; 6.1% (14.1%) and 3.8% (8.1%) for cord; 3.1% (17.5%) and 6.2% (9.8%) for proximal bronchial tree; and 17.7% (19.5%) and 14.1% (17%) for aorta. CONCLUSION: Online CBCT guidance improves the accuracy of target dose delivery for lung SBRT. However, treatment dose to normal tissue can vary regardless of the correction. Normal tissues should be considered during target registration, according to target proximity. |
| | |
Authors:
|
Ana Paula Galerani; Inga Grills; Geoffrey Hugo; Larry Kestin; Nasiruddin Mohammed; K Kenneth Chao; Andrew Suen; Alvaro Martinez; Di Yan |
Related Documents
:
|
22124937 - Imaging and quantification of metastatic melanoma cells in lymph nodes with a ferritin ... 21761267 - Nuclear myocardial perfusion imaging with a novel cadmium-zinc-telluride detector spect... 21623237 - Radiological changes after stereotactic radiotherapy for stage i lung cancer. 22124387 - Organ volume by computed tomography correlates with longitudinal axis on ultrasound in ... 20432007 - Vascular anomalies: what a radiologist needs to know. 18843867 - 3d geometrical assessment of femoral curvature: a reverse engineering technique. |
Publication Detail:
|
Type: Journal Article Date: 2010-06-18 |
Journal Detail:
|
Title: International journal of radiation oncology, biology, physics Volume: 78 ISSN: 1879-355X ISO Abbreviation: Int. J. Radiat. Oncol. Biol. Phys. Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-11-24 Completed Date: 2010-12-17 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7603616 Medline TA: Int J Radiat Oncol Biol Phys Country: United States |
Other Details:
|
Languages: eng Pagination: 1571-8 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Radiation Oncology, Clinirad, Angelina Caron Hospital, Curitiba, Parana, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Carcinoma, Non-Small-Cell Lung* / pathology, radiography, surgery Cone-Beam Computed Tomography* Female Humans Lung / radiography* Lung Neoplasms* / pathology, radiography, surgery Male Middle Aged Movement* Organs at Risk / radiography Radiosurgery / methods* Radiotherapy Planning, Computer-Assisted / methods* Respiration Tumor Burden |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The effects of comorbidity and age on RTOG study enrollment in Stage III non-small cell lung cancer ...
Next Document: Monotherapeutic high-dose-rate brachytherapy for prostate cancer: five-year results of an extreme hy...