| Dose-volume considerations in radiosurgery. | |
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MedLine Citation:
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PMID: 1667045 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dose-volume effects are very important in radiosurgery. Functional radiosurgery illustrates brain tolerance at the extremes of small volumes and high radiation doses. The risks of radiation necrosis from radiosurgery of arteriovenous malformations (AVMs) and tumors appear to be reasonably well predicted by the integrated logistic formula and the 1% dose-volume isoeffect line for proton beam irradiation. The two main exceptions to this rule are cranial nerves, which appear to be more sensitive than the rest of the brain, and angiographically occult vascular malformations, where complications appear to occur at lower doses/volumes than in the treatment of tumors or AVMs. Further investigation is needed to better predict complications throughout the entire range of volumes, radiation doses, treatment locations and techniques presently used in stereotactic radiosurgery. |
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Authors:
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J C Flickinger; L D Lunsford; D Kondziolka |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Stereotactic and functional neurosurgery Volume: 57 ISSN: 1011-6125 ISO Abbreviation: Stereotact Funct Neurosurg Publication Date: 1991 |
Date Detail:
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Created Date: 1992-05-21 Completed Date: 1992-05-21 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8902881 Medline TA: Stereotact Funct Neurosurg Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 99-105 Citation Subset: IM |
Affiliation:
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Department of Radiation Oncology, University of Pittsburgh School of Medicine, Pa. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Brain
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pathology,
radiation effects Cerebral Angiography Cranial Nerves / radiation effects Dose-Response Relationship, Radiation Humans Intracranial Arteriovenous Malformations / radiography, surgery Models, Neurological Necrosis Probability Protons Radiosurgery* |
| Chemical | |
Reg. No./Substance:
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0/Protons |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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