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Dose- and time-response analysis of total fatty acid ethyl esters in meconium as a biomarker of prenatal alcohol exposure.
MedLine Citation:
PMID:  24691675     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES: Little is known on how the dose and timing of exposure co-influence the cumulative concentration of fatty acids ethyl esters (FAEEs) in meconium. The objective of the study was to assess the cumulative concentration of FAEEs in meconium as a biomarker of light, moderate or heavy prenatal alcohol exposure occurring at either first, second or third trimester of pregnancy.
METHODS: History of prenatal alcohol exposure was obtained in the 34(th) week of gestation from 294 pregnant women. Meconium was collected from their babies within the first 6-12 hours after birth, and examined for the presence of nine FAEEs.
RESULTS: No significant differences were identified between the cumulative levels of FAEEs in the meconium from the babies born to abstainers and those born to mothers with history of light-to-moderate prenatal alcohol exposure during their pregnancy.
CONCLUSIONS: Light-to-moderate prenatal alcohol exposure cannot be reliably predicted by the cumulative FAEE concentrations in meconium of exposed babies. A cumulative FAEE level >10 nmol/g would be required to consider that prenatal alcohol exposure during the 2(nd) -3(rd) trimesters occurred at risky levels in the absence of reliable maternal history of ethanol exposure. This article is protected by copyright. All rights reserved.
Authors:
Ho-Seok Kwak; Jung-Yeol Han; June-Seek Choi; Hyun-Kyong Ahn; Dong-Wook Kwak; Yeon-Kyung Lee; Sun-Young Koh; Go-Un Jeong; E Yadira Velázquez-Armenta; Alejandro A Nava-Ocampo
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-4-1
Journal Detail:
Title:  Prenatal diagnosis     Volume:  -     ISSN:  1097-0223     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-4-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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