Document Detail


Dose response to vitamin D supplementation in African Americans: results of a 4-arm, randomized, placebo-controlled trial.
MedLine Citation:
PMID:  24368437     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Association studies have suggested that lower circulating 25-hydroxyvitamin D [25(OH)D] in African Americans may partially underlie higher rates of cardiovascular disease and cancer in this population. Nonetheless, the relation between vitamin D supplementation and 25(OH)D concentrations in African Americans remains undefined.
OBJECTIVE: Our primary objective was to determine the dose-response relation between vitamin D and plasma 25(OH)D.
DESIGN: A total of 328 African Americans in Boston, MA, were enrolled over 3 winters from 2007 to 2010 and randomly assigned to receive a placebo or 1000, 2000, or 4000 IU vitamin D₃/d for 3 mo. Subjects completed sociodemographic and dietary questionnaires, and plasma samples were drawn at baseline and 3 and 6 mo.
RESULTS: Median plasma 25(OH)D concentrations at baseline were 15.1, 16.2, 13.9, and 15.7 ng/mL for subjects randomly assigned to receive the placebo or 1000, 2000, or 4000 IU/d, respectively (P = 0.63). The median plasma 25(OH)D concentration at 3 mo differed significantly between supplementation arms at 13.7, 29.7, 34.8, and 45.9 ng/mL, respectively (P < 0.001). An estimated 1640 IU vitamin D₃/d was needed to raise the plasma 25(OH)D concentration to ≥ 20 ng/mL in ≥ 97.5% of participants, whereas a dose of 4000 IU/d was needed to achieve concentrations ≥ 33 ng/mL in ≥ 80% of subjects. No significant hypercalcemia was seen in a subset of participants.
CONCLUSIONS: Within African Americans, an estimated 1640 IU vitamin D₃/d was required to achieve concentrations of plasma 25(OH)D recommended by the Institute of Medicine, whereas 4000 IU/d was needed to reach concentrations predicted to reduce cancer and cardiovascular disease risk in prospective observational studies. These results may be helpful for informing future trials of disease prevention.
Authors:
Kimmie Ng; Jamil B Scott; Bettina F Drake; Andrew T Chan; Bruce W Hollis; Paulette D Chandler; Gary G Bennett; Edward L Giovannucci; Elizabeth Gonzalez-Suarez; Jeffrey A Meyerhardt; Karen M Emmons; Charles S Fuchs
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2013-12-24
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  99     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-02-21     Completed Date:  2014-05-02     Revised Date:  2014-11-05    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  587-98     Citation Subset:  AIM; IM    
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00585637
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MeSH Terms
Descriptor/Qualifier:
Adult
African Americans
Aged
Aged, 80 and over
Boston / epidemiology
Calcifediol / blood*
Cardiovascular Diseases / epidemiology,  ethnology,  etiology,  prevention & control*
Cholecalciferol / administration & dosage,  adverse effects,  therapeutic use*
Cohort Studies
Dietary Supplements* / adverse effects
Double-Blind Method
Female
Humans
Intention to Treat Analysis
Lost to Follow-Up
Male
Middle Aged
Neoplasms / epidemiology,  ethnology,  etiology,  prevention & control*
Patient Dropouts
Risk Factors
Seasons
Vitamin D Deficiency / blood,  diet therapy*,  ethnology,  physiopathology
Grant Support
ID/Acronym/Agency:
K07 CA148894/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
1C6V77QF41/Cholecalciferol; P6YZ13C99Q/Calcifediol
Comments/Corrections
Comment In:
Am J Clin Nutr. 2014 Sep;100(3):982-4   [PMID:  25142889 ]
Am J Clin Nutr. 2014 Sep;100(3):984-6   [PMID:  25142890 ]
Am J Clin Nutr. 2014 Mar;99(3):427-8   [PMID:  24452230 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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