Document Detail

Dose response of thyrotropin-releasing hormone on pulmonary maturation in corticosteroid-treated preterm rabbits.
MedLine Citation:
PMID:  2117393     Owner:  NLM     Status:  MEDLINE    
The dose-response effect of thyrotropin-releasing hormone in enhancing pulmonary maturation was investigated with six dosing regimens. Pregnant does received thyrotropin-releasing hormone (5, 10, or 50 micrograms/kg every 12 hours for four doses or one dose of 20 micrograms/kg) in conjunction with betamethasone beginning on day 25 of gestation, with betamethasone alone or saline solution used as comparison treatment groups. Half of the newborn rabbits received supplemental surfactant therapy after delivery on day 27, and all were ventilated on a ventilator plethysmography system for 30 minutes. There were no differences among the four thyrotropin-releasing hormone doses in surfactant pool sizes, compliances, or proteins leak into or out of the air spaces. The groups that received multiple doses of thyrotropin-releasing hormone had significantly higher perinatal loss rates than the single-dose group. The lungs of the group treated with thyrotropin-releasing hormone plus steroid and the rabbits treated only with steroid were more compliant than the controls without surfactant therapy, and showed significant improvements in protein leak. The addition of thyrotropin-releasing hormone to betamethasone improved several of the protein leak measurements compared with use of betamethasone alone. These results question the necessity of multiple doses of thyrotropin-releasing hormone to induce pulmonary maturation, especially when the higher perinatal mortality and the theoretical long-term effects of fetal hyperthyroidism on thyroid axis function are considered.
B L Tabor; M Ikegami; A H Jobe; T Yamada; S B Oetomo
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  163     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1990-09-14     Completed Date:  1990-09-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  669-76     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Harbor-UCLA Medical Center, Torrance 90509.
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MeSH Terms
Animals, Newborn*
Betamethasone / therapeutic use*
Dose-Response Relationship, Drug
Fetal Organ Maturity / drug effects
Infant, Newborn
Lung / embryology*
Pulmonary Surfactants / therapeutic use
Respiratory Distress Syndrome, Newborn / prevention & control
Thyrotropin-Releasing Hormone / administration & dosage,  therapeutic use*
Grant Support
Reg. No./Substance:
0/Pulmonary Surfactants; 24305-27-9/Thyrotropin-Releasing Hormone; 378-44-9/Betamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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