Document Detail


Dose-response relationships between iron deficiency with or without anemia and infant social-emotional behavior.
MedLine Citation:
PMID:  18410777     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To assess dose-response relationships between severity of iron deficiency (ID) and infant social-emotional behavior.
STUDY DESIGN: The study group was a cohort of 9- to 10-month-old African-American infants (n = 77 with final iron status classification). The infants were given oral iron for 3 months. Social-emotional outcomes included mother and examiner ratings at 9 and 12 months and quantitative behavioral coding from videotape at 12 months. General linear model analyses tested for linear effects of iron status group (ordered from worst to best: iron-deficient anemia [IDA], nonanemic iron-deficient [NA ID], iron-sufficient [IS]) and determined thresholds for effects.
RESULTS: There were significant (P <.05) linear effects of poorer iron status for shyness (increasing, maternal rating), orientation-engagement, and soothability (decreasing, examiner ratings), and the following quantitatively coded behaviors: positive affect (decreasing) and latencies to engage with the examiner (increasing) and move away from the examiner (decreasing). The threshold for all but 1 effect was ID with or without anemia versus IS.
CONCLUSIONS: Infant social-emotional behavior appears to be adversely affected by ID with or without anemia. ID without anemia is not detected by common screening procedures and is more widespread than IDA. Infant social-emotional behavior can profoundly influence the care-giving environment, with repercussions for overall development.
Authors:
Betsy Lozoff; Katy M Clark; Yuezhou Jing; Rinat Armony-Sivan; Mary Lu Angelilli; Sandra W Jacobson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-11-19
Journal Detail:
Title:  The Journal of pediatrics     Volume:  152     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-15     Completed Date:  2008-05-06     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  696-702, 702.31-3     Citation Subset:  AIM; IM    
Affiliation:
Center for Human Growth and Development, University of Michigan, Ann Arbor, MI 48109-5406, USA. blozoff@umich.edu
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MeSH Terms
Descriptor/Qualifier:
African Americans / psychology
Anemia, Iron-Deficiency / ethnology,  psychology*
Case-Control Studies
Emotions / physiology*
Female
Humans
Infant
Infant Behavior / physiology*
Male
Severity of Illness Index
Social Behavior*
Socioeconomic Factors
Urban Health
Grant Support
ID/Acronym/Agency:
P01 HD039386/HD/NICHD NIH HHS; P01 HD039386-01A1/HD/NICHD NIH HHS; P01 HD039386-01A10001/HD/NICHD NIH HHS; P01 HD039386-02/HD/NICHD NIH HHS; P01 HD039386-020001/HD/NICHD NIH HHS; P01 HD039386-03/HD/NICHD NIH HHS; P01 HD039386-04/HD/NICHD NIH HHS; P01 HD039386-05/HD/NICHD NIH HHS; P01 HD039386-06A1/HD/NICHD NIH HHS; P01 HD039386-06A16492/HD/NICHD NIH HHS; P01 HD039386-06A18167/HD/NICHD NIH HHS; P01 HD039386-06A18701/HD/NICHD NIH HHS; P01 HD39386/HD/NICHD NIH HHS
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