Document Detail


Dose-response relationships of alimentary PtCl2 and PtCl4 in growing rats.
MedLine Citation:
PMID:  1483037     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In experiments with rats dose-response relationships of alimentary PtCl2 and PtCl4 were investigated. 2 x 81 animals weighing 35 g were randomly distributed among 9 treatment groups which were fed ad libitum with a synthetic diet containing various amounts of Pt during 4 weeks. Pt was added in the form of PtCl2 or PtCl4 in the amounts 0; 0.01; 0.05; 0.10; 0.50; 1.0; 5.0; 10 and 50 mg/kg diet. The Pt supplementation had no influence on life mass gain or food consumption. In the case of 50 mg/kg Pt in the form of PtCl4 the erythrocyte count and hematocrit were reduced by about 13% in comparison with the control group. Dependent on the Pt dose, the application of PtCl4 and PtCl2 induced Pt retention in nearly all tissues especially in kidney. The effects were greater with PtCl4 than with PtCl2. As a result of the higher Pt retention in the kidneys, the serum creatinine was increased for the higher doses of PtCl4.
Authors:
A M Reichlmayr-Lais; M Kirchgessner; R Bader
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of trace elements and electrolytes in health and disease     Volume:  6     ISSN:  0931-2838     ISO Abbreviation:  J Trace Elem Electrolytes Health Dis     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1993-02-12     Completed Date:  1993-02-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8807101     Medline TA:  J Trace Elem Electrolytes Health Dis     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  183-7     Citation Subset:  IM    
Affiliation:
Institut für Ernährungsphysiologie, Technische Universität München, Freising-Weihenstephan, Fed. Rep. of Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight / drug effects
Diet
Dose-Response Relationship, Drug
Eating / drug effects
Erythrocyte Count / drug effects*
Hematocrit
Hemoglobins / analysis
Male
Platinum / administration & dosage,  pharmacokinetics,  toxicity*
Platinum Compounds*
Rats
Rats, Sprague-Dawley
Tissue Distribution
Chemical
Reg. No./Substance:
0/Hemoglobins; 0/Platinum Compounds; 12648-47-4/platinum chloride; 13454-96-1/platinum tetrachloride; 7440-06-4/Platinum

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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