Document Detail

Dose-response relationship between ingested arsenic and cataracts among residents in Southwestern Taiwan.
MedLine Citation:
PMID:  17952785     Owner:  NLM     Status:  MEDLINE    
This association study was carried out to examine the effect of long-term exposure to ingested arsenic on various types of cataract. A total of 349 residents living in arseniasis-hyperendemic villages of southwestern Taiwan were recruited. Cumulative arsenic exposure was derived from the history of consuming artesian well water and the arsenic level in well water. The Lens Opacities System III was used to classify different types of cataract. The cataract surgery prevalence was 10% for the age group of 50 or more years. Cortical opacity was most common (35%), while nuclear and posterior subcapsular opacities were observed in 24% and 22% of subjects, respectively. Diabetes mellitus was a significant risk factor for all types of cataract. Occupational sunlight exposure was associated with cortical and posterior subcapsular opacities in a dose-response relationship. The cumulative exposure to arsenic from artesian well water and the duration of consuming artesian well water were associated with an increased risk of all types of lens opacity. But statistically significant dose-response relations with the cumulative arsenic exposure and the duration of consuming artesian well water were observed only for posterior subcapsular opacity (P=0.014 and P=0.023, respectively) after adjustment for age, sex, diabetes status, and occupational sunlight exposure. It was concluded that there was an increasing prevalence of posterior subcapsular opacity with the increase in exposure to ingested arsenic.
Lai-Chu See; Hung-Yi Chiou; Jiahn-Shing Lee; Yu-Mei Hsueh; Shu-Mei Lin; Ming-Chang Tu; Meng-Ling Yang; Chien-Jen Chen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering     Volume:  42     ISSN:  1093-4529     ISO Abbreviation:  J Environ Sci Health A Tox Hazard Subst Environ Eng     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-22     Completed Date:  2008-02-26     Revised Date:  2009-08-14    
Medline Journal Info:
Nlm Unique ID:  9812551     Medline TA:  J Environ Sci Health A Tox Hazard Subst Environ Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1843-51     Citation Subset:  IM    
Department of Public Health, College of Medicine, Chang Gung University, Taiwan.
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MeSH Terms
Age Distribution
Aged, 80 and over
Arsenic / administration & dosage,  analysis*
Cataract / epidemiology,  etiology*
Cataract Extraction / statistics & numerical data
Environmental Exposure / adverse effects,  analysis
Middle Aged
Occupational Exposure / adverse effects,  analysis
Odds Ratio
Risk Factors
Sex Distribution
Sunlight / adverse effects
Taiwan / epidemiology
Water Pollutants, Chemical / analysis,  poisoning*
Water Supply / analysis*
Reg. No./Substance:
0/Water Pollutants, Chemical; 7440-38-2/Arsenic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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