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Dose-response effects of exercise on abdominal obesity and risk factors for cardiovascular disease in adults: Study rationale, design and methods.
MedLine Citation:
PMID:  23123790     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Although progress has been made to elucidate the effects of exercise as a strategy for reducing obesity and related cardiometabolic risk factors, the specific exercise exposures required to achieve optimal benefit continue to be the source of considerable uncertainty and debate. Despite the inference of a dose-dependent relationship between exercise and health benefit, absent from the literature are randomized trials that, without alteration in caloric intake, examine the separate effects of exercise dose and intensity on obesity and associated cardiometabolic risk. We will perform a randomized, controlled trial designed to study the separate effects of habitual exercise differing in dose (energy expenditure, kcal/session) and intensity (relative to VO(2)peak) on abdominal obesity and selected cardiometabolic risk factors. The primary outcomes are waist circumference and 2-hr glucose. We will randomly assign 320 sedentary, abdominally obese men (N=160) and women (N=160) to one of 4 conditions: 1) No-exercise control, 2) Low volume, low intensity exercise, 3) High volume, low intensity exercise, 4) High volume, high intensity exercise. Duration of all treatments will be 6months. The findings from this study may help resolve the following unanswered questions, "For a given exercise dose does higher exercise intensity result in greater health benefits?" "For a given exercise intensity does higher exercise dose result in greater health benefits?". Identification of the separate effects of exercise dose and intensity on obesity and related cardiometabolic risk factors under controlled conditions are important for development of optimal, lifestyle-based strategies that can subsequently be tested in long-term effectiveness trials.
Authors:
Robert Ross; Robert Hudson; Andrew G Day; Miu Lam
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-31
Journal Detail:
Title:  Contemporary clinical trials     Volume:  -     ISSN:  1559-2030     ISO Abbreviation:  Contemp Clin Trials     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-11-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101242342     Medline TA:  Contemp Clin Trials     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Inc.
Affiliation:
School of Kinesiology and Health Studies, Queen's University, Kingston, ON, Canada; School of Medicine, Department of Endocrinology and Metabolism, Queen's University, Kingston, Ontario, Canada. Electronic address: rossr@queensu.ca.
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